Results 101 to 110 of about 102,342,057 (307)
Effect of telephone follow-up on retention and balance in an alcohol intervention trial
Preventive Medicine Reports, 2015 Objectives: Telephone follow-up is not currently recommended as a strategy to improve retention in randomized trials. The aims of this study were to estimate the effect of telephone follow-up on retention, identify participant characteristics predictive ...
Natalie A. Johnson +10 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Factors associated with retention in HIV care at Sediba Hope Medical Centre
Southern African Journal of HIV Medicine, 2015 Background: Lost to follow-up (LTFU) is a major challenge that hinders the success of antiretroviral treatment (ART). Objective: To identify factors conducted to a low LTFU rate. Methods: We conducted a two-part descriptive and quantitative study. Part
Nishana Ramdas +2 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Number and proportion of patients lost to follow-up, by sex and age groups, 2006–2015.
, 2018 (a) Number of patients lost to follow-up, by age and sex groups. (b) Proportion of patients lost to follow-up, by age and sex groups.
Seiya Kato (206493) +3 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
International principles for best practice EIA follow-up [PDF]
, 2005 This article presents principles for best practice environmental impact assessment (EIA) follow-up. These are intended to guide development and capacity building amongst EIA practitioners.
Arts, J. +2 more
core
Drop out in a clinic of preterm development follow-up: rates and causes
Cadernos Brasileiros de Terapia Ocupacional, 2018 Objective: To make a survey of the dropping out rate and investigate its possible causes in preterm infants follow-up program. Method: Descriptive study, using the quantitative and qualitative methodology, developed in a follow-up preterm born children ...
Mariana Lacerda Gontijo +3 more
doaj