Results 111 to 120 of about 493,362 (305)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A dynamic lot-sizing model with demand time windows
One of the basic assumptions of the classical dynamic lot-sizing model is that the aggregate demand of a given period must be satisfied in that period.
Lee, C.Y. +2 more
core
Remanufacturing lot-sizing under alternative perceptions of returned units' quality [PDF]
International Journal of Business Science and Applied Management, 2012 One of the critical parameters in reverse supply chain management is the increased variability of the quality condition of used, returned products. The volatile nature of returns' quality often dictates the establishment of quality assessment procedures ...
Zikopoulos, C.
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
On the complexity of the economic lot-sizing problem with remanufacturing options
In this paper we investigate the complexity of the economiclot-sizing problem with remanufacturing (ELSR) options. Whereas inthe classical economic lot-sizing problem demand can only besatisfied by production, in the ELSR problem demand can also ...
Heuvel, W. van den
core
Multi-Level Lot Sizing Problem with Deterioration Inventory and Disposal Costs
مدیریت تولید و عملیات, 2016 In this paper, the multi-level lot sizing problem which is used to determine the production lot sizes in industrial environments, has been investigated.
Mahmood Vahdani, Ardeshir Dolati
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Improved Lower Bounds For The Capacitated Lot Sizing Problem With Set Up Times
We present new lower bounds for the Capacitated Lot Sizing Problem with Set Up Times. We improve the lower bound obtained by the textbook Dantzig-Wolfe decomposition where the capacity constraints are the linking constraints.
Degraeve, Z., Jans, R.F.
core
Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2015 Material Requirement Planning (MRP) adalah suatu metode yang digunakan untuk mengendalikan persediaan bahan baku pada perusahaan. Suatu perusahaan untuk menerapkan kebijakan-kebijakan dalam perencanaan bahan baku harus memiliki perhitungan yang tepat ...
Asvin Wahyuni, Achmad Syaichu
doaj
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source