Results 131 to 140 of about 493,362 (305)
The textbook Dantzig-Wolfe decomposition for the Capacitated LotSizing Problem (CLSP),as already proposed by Manne in 1958, has animportant structural deficiency.
Degraeve, Z., Jans, R.F.
core
A computational analysis of lower bounds for big bucket production planning problems
, 2012 In this paper, we analyze a variety of approaches to obtain lower bounds for multi-level production planning problems with big bucket capacities, i.e., problems in which multiple items compete for the same resources.
Akartunali, Kerem, Miller, Andrew J.
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A holding cost bound for the economic lot-sizing problem with time-invariant cost parameters
In this paper we derive a new structural property for an optimal solution of the economic lot-sizing problem with time-invariant cost parameters. We show that the total holding cost in an order interval of an optimal solution is bounded from above by a ...
Wagelmans, A.P.M., Heuvel, W.J. van den
core
An O(Tˆ3) algorithm for the capacitated lot sizing problem with minimum order quantities [PDF]
This paper explores a single-item capacitated lot sizing problem with minimum order quantity, which plays the role of minor set-up cost. We work out the necessary and suffcient solvability conditions and apply the general dynamic programming technique to
Okhrin, Irena, Richter, Knut
core
ComputationIn inventory management, storage capacity constraints complicate multi-item lot-sizing decisions. As the number of items increases, deciding how much of each item to order without exceeding capacity becomes more difficult.
Warut Boonphakdee +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source