Results 141 to 150 of about 493,362 (305)

Dynamic Programming Algorithms for Lot-Sizing Problems

open access: yes
Lot-sizing problem has been extensively researched in many aspects. In this review, we summarize key points of dynamic programming algorithms in lot-sizing problems and give some hints helping further designing algorithms for more variations of lot ...
ザン, ピン, Zhan, Ping
core  

Optimizing campaign sizing policies: an application to a real-life setting. [PDF]

open access: yes
This paper presents an integrated production inventory model that enables to capture the tradeoffs between average inventory, production capacity and customer service level in a semiprocess industry setting. The model includes different features that are
Van Nieuwenhuyse, Inneke   +2 more
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Lot-sizing: production planning methods and models

open access: yes
openProgrammazione lineare intera mista, programmazione dinamica, modelli di pianificazione della produzione, The Uncapacitated Lot-sizing problem (LS-U), variante di LS-U con vendite e scorte di sicurezza, variante di LS-U con costi fissi di stoccaggio ...
CIUFFREDA, SARA
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Some new properties for capacitated lot-sizing problem with bounded inventory and stockouts

open access: yes, 2004
Some new properties for capacitated lot-sizing problem with bounded inventory and ...
Chu F(储峰)   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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