FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mathematical Programming for Lot Sizing and Production Scheduling in Foundries
Archives of Foundry Engineering, 2014 The problem considered in the paper is motivated by production planning in a foundry equipped with the furnace and casting line, which provides a variety of castings in various grades of cast iron/steel for a large number of customers.
Duda J., Stawowy A., Basiura R.
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Lot Sizing Based on Stochastic Demand and Service Level Constraint
مدیریت تولید و عملیات, 2012 Considering its application, stochastic lot sizing is a significant subject in production planning. Also the concept of service level is more applicable than shortage cost from managers' viewpoint.
hajar shirneshan +2 more
doaj
A Model Predictive Control for Lot Sizing and Scheduling Optimization in the Process Industry under Bidirectional Uncertainty of Production Ability and Market Demand. [PDF]
Comput Intell Neurosci, 2022 Tang Q, Wang Y.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A sustainable supply chain network considering lot sizing with quantity discounts under disruption risks: centralized and decentralized models. [PDF]
J Comb Optim, 2022 Rafigh P +3 more
europepmc +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Integrating supplier selection, lot sizing and facility location decisions under a TBL approach: a case study. [PDF]
Soft comput, 2022 Alegoz M, Yapicioglu H.
europepmc +1 more source