Results 61 to 70 of about 317,672 (284)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Samuel Pepys and his experiences of music at Restoration theatres [PDF]

open access: yes, 2017
Restoration London was replete with opportunities to listen to music, even before the first public concerts were established. The Restoration theatre was one of the venues where Londoners had ample opportunity to listen to the newest compositions ...
Wiesecke, J.
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

From Latin to Latino Lover: Hispanicity and Female Desire in Popular Culture

open access: yesJournal of Popular Romance Studies, 2014
This article examines the relationship between the concept of the Latin Lover and the notion of Hispanicity. The essay starts with an analysis of The Sheik (1921), which is generally considered as the film that launched the figure of the Latin Lover. The
Nadia Lie
doaj  

Good soldier, better politician, charming lover

open access: yesCrossings, 2009
Caesar: Life of a Colossus Adrian Goldsworthy Phoenix: Yale University Press, 2006 Julius Caesar disregarded warnings about the Ides of March. He believed, as Shakespeare would have us know, that he was more dangerous than danger itself. That precisely
Syed Badrul Ahsan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Aristotle on Virtue of Character and the Authority of Reason [PDF]

open access: yes, 2019
I argue that, for Aristotle, virtue of character is a state of the non-rational part of the soul that makes one prone to making and acting on decisions in virtue of that part’s standing in the right relation to (correct) reason, namely, a relation that ...
Müller, Jozef
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

“The country of his past”: Homecoming in “A Modern Lover” and “The Shades of Spring”

open access: yesÉtudes Lawrenciennes
In the two early stories, “A Modern Lover” and “The Shades of Spring,” Lawrence imagines an autobiographical figure returning to his home country to renew connection with the young woman he had loved (a version of Jessie Chambers).
Keith Cushman
doaj   +1 more source

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