Results 51 to 60 of about 319,004 (304)
Revista de Filosofia AntigaThe aim of this paper is to explain why Thrasymachus, upon first appearing in Republic I, prohibits Socrates from defining justice as what is good. I argue that Thrasymachus views such definitions as equivocal, since he conceives of the good as relative:
Clifford Roberts
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Regional initiatives for malaria elimination: Building and maintaining partnerships.
PLoS Medicine, 2017 Andrew Lover and colleagues discuss regional malaria initiatives, the strengths and challenges.
Andrew A Lover +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Felsefe Dünyası, 2005 Ömer ÖZDEN, AŞKIN (SEVGİNİN) GÜCÜ, FELSEFE DÜNYASI DERGİSİ, SAYI:42 ...
Ömer Özden
doaj
Samuel Pepys and his experiences of music at Restoration theatres [PDF]
, 2017 Restoration London was replete with opportunities to listen to music, even before the first public concerts were established. The Restoration theatre was one of the venues where Londoners had ample opportunity to listen to the newest compositions ...
Wiesecke, J.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
VALUE OF LIFE PADA MAHASISWA PENIKMAT DUNIA MALAM [PDF]
, 2010 Modernism has made modern value entering societies all over the world. This modern values brought a lifestyle Hedonis society considered as ‘modern’ and became reference of society’s life.
Rosidah, Okta Viatur
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source