Results 121 to 130 of about 96,443 (174)

The Deuterium Isotope Effect on the NMR Signal of the Low-Barrier Hydrogen Bond in a Transition- State Analog Complex of Chymotrypsin

Biochemical and Biophysical Research Communications - BBRC, 2000
The participation of a low-barrier hydrogen bond (LBHB) in the mechanism of action of chymotrypsin introduces a new role for Asp 102 and His 57 in catalysis [C. S. Cassidy, J. Lin, and P. A. Frey (1997) Biochemistry 36, 4576-4584].
Constance S. Cassidy, Jing Lin, Perry A. Frey   +2 more
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A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond.

Biochemistry, 1997
The basicities of the diad H57-D102 at N(epsilon)2 in the tetrahedral complexes of chymotrypsin with the peptidyl trifluoromethyl ketones (TFK) N-acetyl-L-Leu-DL-Phe-CF3 and N-acetyl-DL-Phe-CF3 have been studied by 1H-NMR. The protons bridging His 57 and
C. Cassidy, Jing Lin, Perry A. Frey
semanticscholar   +4 more sources

ChemInform Abstract: Follow the Protons: A Low‐Barrier Hydrogen Bond Unifies the Mechanisms of the Aspartic Proteases

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dexter B. Northrop
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A Novel Engineered Subtilisin BPN‘ Lacking a Low-Barrier Hydrogen Bond in the Catalytic Triad

Biochemistry, 2001
The low-barrier hydrogen bond (LBHB) between the Asp and His residues of the catalytic triad in a serine protease was perturbed via the D32C mutation in subtilisin BPN' (Bacillus protease N').
Jennifer Stratton, Jeffrey G. Pelton, Jack F. Kirsch   +2 more
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Probing the Low-Barrier Hydrogen Bond in Hydrogen Maleate in the Gas Phase: A Photoelectron Spectroscopy and ab Initio Study

Journal of Physical Chemistry A, 2005
The strength of the low-barrier hydrogen bond in hydrogen maleate in the gas phase was investigated by low-temperature photoelectron spectroscopy and ab initio calculations. Photoelectron spectra of maleic and fumaric acid monoanions (cis-/trans-HO(2)CCH=
Hin‐Koon Woo, Xue‐Bin Wang, Lai‐Sheng Wang, Kai‐Chung Lau   +3 more
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Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Journal of Medicinal Chemistry, 2022
Here, we report a novel mechanism to selectively degrade target proteins. 3-(3-Phenoxybenzyl)amino-β-carboline (PAC), a tubulin inhibitor, promotes selective degradation of αβ-tubulin heterodimers.
Jianhong Yang, Yong Li, Q. Qiu, Ruihan Wang, Wei-Qun Yan, Yamei Yu, Lu Niu, Heying Pei, Haoche Wei, Ouyang Liang, Haoyu Ye, Dingguo Xu, Yuquan Wei, Qiang Chen, Lijuan Chen   +14 more
semanticscholar   +1 more source

Low-Barrier Hydrogen Bonds and Enzymic Catalysis [PDF]

Science, 1994
Formation of a short (less than 2.5 angstroms), very strong, low-barrier hydrogen bond in the transition state, or in an enzyme-intermediate complex, can be an important contribution to enzymic catalysis. Formation of such a bond can supply 10 to 20 kilocalories per mole and thus facilitate difficult reactions such as enolization of ...
Maurice M. Kreevoy, W. Wallace Cleland
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Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme CoIII(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds.

Journal of the American Chemical Society, 2023
Introduction of Brønsted acids into biomimetic nonheme reactions promotes the oxidative ability of metal-oxygen complexes significantly. However, the molecular machinery of the promoted effects is missing. Herein, a comprehensive investigation of styrene
Dongru Sun, Zhiyong Wu, Xuan Zhang, Jindou Yang, Yufen Zhao, W. Nam, Yong Wang   +6 more
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The low barrier hydrogen bond (LBHB) proposal revisited: The case of the Asp ··· His pair in serine proteases

Proteins: Structure, Function, and Bioinformatics, 2004
Claudia Schütz, Arieh Warshel
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Low-barrier hydrogen bonds in proteins

Crystallography Reviews, 2013
Hydrogen bonding interactions are one of the most important chemical interactions among materials, especially biological materials, which help confer specificity, which is crucial for their efficient functioning. Recently, low-barrier hydrogen bonds (LBHBs) have been proposed to play a critical role in enzyme catalysis.
R.R. Choudhury, M. V. Hosur, Amit Das, Samarth Hegde, R. Chitra, Ramakrishna V. Hosur   +5 more
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