Results 151 to 160 of about 230,876 (232)

Low-Barrier Hydrogen Bond between Phosphate and the Amide Group in Phosphopeptide

Journal of the American Chemical Society, 2005
As the conversion between the monoionic (1) and diionic (2) form of the phosphate occurs, the phosphorylated peptides or proteins can not only cause the formation of a hydrogen bond between the phosphate group and the amide group but also change the strength of the hydrogen bond to form low-barrier hydrogen bonds (LBHBs). This reversible protonation of
Jintang Du, Yanmei Li, Wei Wei, Guoshi Wu, Yufen Zhao, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi   +7 more
semanticscholar   +5 more sources

Theoretical Study of the Low-Barrier Hydrogen Bond in the Hydrogen Maleate Anion in the Gas Phase. Comparison with Normal Hydrogen Bonds

Journal of the American Chemical Society, 1997
Relative strengths of normal and low-barrier hydrogen bonds (LBHBs) in the gas phase were analyzed by means of quantum-mechanical and thermodynamic calculations on the mesaconic/citraconic and several maleic/fumaric cis/trans isomerization equilibria. All geometries were fully optimized with correlation effects included via second-order Moller−Plesset ...
Mireia Garcia‐Viloca, Àngels González–Lafont, José M. Lluch   +2 more
semanticscholar   +4 more sources

Transient low-barrier hydrogen bond in the photoactive state of green fluorescent protein

Physical Chemistry Chemical Physics, 2015
A transient low-barrier hydrogen bond has been found directly after photoexcitation using quantum dynamics to study the excited-state process in GFP.
Marc Nadal-Ferret, Ricard Gelabert, Miquel Moreno, José M. Lluch   +3 more
semanticscholar   +5 more sources

The Low Barrier Hydrogen Bond in Enzymatic Catalysis* [PDF]

Journal of Biological Chemistry, 1998
W. Cleland, P. Frey, J. Gerlt
semanticscholar   +4 more sources

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A low-barrier hydrogen bond in the catalytic triad of serine proteases.

Science, 1994
Spectroscopic properties of chymotrypsin and model compounds indicate that a low-barrier hydrogen bond participates in the mechanism of serine protease action. A low-barrier hydrogen bond between Nδ1 of His 57 and the β-carboxyl group of Asp 102 in chymotrypsin can facilitate the formation of
P. Frey, S. A. Whitt, John B. Tobin
semanticscholar   +4 more sources

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Journal of Medicinal Chemistry, 2022
Here, we report a novel mechanism to selectively degrade target proteins. 3-(3-Phenoxybenzyl)amino-β-carboline (PAC), a tubulin inhibitor, promotes selective degradation of αβ-tubulin heterodimers.
Jianhong Yang, Yong Li, Q. Qiu, Ruihan Wang, Wei-Qun Yan, Yamei Yu, Lu Niu, Heying Pei, Haoche Wei, Ouyang Liang, Haoyu Ye, Dingguo Xu, Yuquan Wei, Qiang Chen, Lijuan Chen   +14 more
semanticscholar   +1 more source

Low-Barrier Hydrogen Bonds and Enzymic Catalysis [PDF]

Science, 1994
Formation of a short (less than 2.5 angstroms), very strong, low-barrier hydrogen bond in the transition state, or in an enzyme-intermediate complex, can be an important contribution to enzymic catalysis. Formation of such a bond can supply 10 to 20 kilocalories per mole and thus facilitate difficult reactions such as enolization of ...
Maurice M. Kreevoy, W. Wallace Cleland
openaire   +3 more sources

Hydrogen-bond networks: strengths of different types of hydrogen bonds and an alternative to the low barrier hydrogen-bond proposal.

Journal of the American Chemical Society, 2013
We report quantifying the strengths of different types of hydrogen bonds in hydrogen-bond networks (HBNs) via measurement of the adiabatic electron detachment energy of the conjugate base of a small covalent polyol model compound (i.e., (HOCH2CH2CH(OH)CH2)2CHOH) in the gas phase and the pKa of the corresponding acid in DMSO.
Alireza Shokri, Yanping Wang, G. O'Doherty, Xue‐Bin Wang, S. Kass   +4 more
semanticscholar   +4 more sources

Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme CoIII(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds.

Journal of the American Chemical Society, 2023
Introduction of Brønsted acids into biomimetic nonheme reactions promotes the oxidative ability of metal-oxygen complexes significantly. However, the molecular machinery of the promoted effects is missing. Herein, a comprehensive investigation of styrene
Dongru Sun, Zhiyong Wu, Xuan Zhang, Jindou Yang, Yufen Zhao, W. Nam, Yong Wang   +6 more
semanticscholar   +1 more source

Low-barrier hydrogen bonds in proteins

Crystallography Reviews, 2013
Hydrogen bonding interactions are one of the most important chemical interactions among materials, especially biological materials, which help confer specificity, which is crucial for their efficient functioning. Recently, low-barrier hydrogen bonds (LBHBs) have been proposed to play a critical role in enzyme catalysis.
R.R. Choudhury, M. V. Hosur, Amit Das, Samarth Hegde, R. Chitra, Ramakrishna V. Hosur   +5 more
openaire   +2 more sources