Results 181 to 190 of about 230,876 (232)
Ab Initio QM/MM Study of the Citrate Synthase Mechanism. A Low-Barrier Hydrogen Bond Is not Involved
, 2000 Adrian J. Mulholland +2 more
openalex +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The low-barrier hydrogen bond in enzymic catalysis
2010Publisher Summary This chapter describes the various aspects of the low-barrier hydrogen bond in enzymic catalysis. Hydrogen bonds come in a continuum of bond lengths and strengths. The first examples of enzymatic reactions where low-barrier hydrogen bonds played a role involved enolization of the substrate to change the p K of a key group in the ...
openaire +2 more sources
On the Possibility of Using UV Spectroscopy as a Measure of the Low-Barrier Hydrogen Bond
Structural Chemistry, 2003In many enzyme-catalyzed biochemical pathways, a short, strong hydrogen bond between an enzyme and substrate is an important structural feature. These bonds are termed low-barrier hydrogen bonds. In this paper, we show that UV spectra can be used as an experimental technique to determine if a system contains a low-barrier hydrogen bond (LBHB).
Jeffrey E. Miller +3 more
openaire +2 more sources
Are There Really Low-Barrier Hydrogen Bonds in Proteins? The Case of Photoactive Yellow Protein
Journal of the American Chemical Society, 2014For a long time, low-barrier hydrogen bonds (LBHBs) have been proposed to exist in many enzymes and to play an important role in their catalytic function, but the proof of their existence has been elusive. The transient formation of an LBHB in a protein system has been detected for the first time using neutron diffraction techniques on a photoactive ...
José M. Lluch +3 more
openaire +3 more sources
Characterization of a low barrier hydrogen bond in the active site of chymotrypsin
Journal of Molecular Structure, 2002Abstract The possibility of strong hydrogen bonding in aqueous solutions is supported by spectroscopic and chemical properties of proton sponges and internally strained dicarboxylic acid monoanions in aqueous and aqueous/acetone solutions. A species of low barrier hydrogen bond (LBHB) in aqueous solutions is the downfield proton in transition state ...
openaire +2 more sources
Spectral Signatures of Proton-Transfer Dynamics at the Cusp of Low-Barrier Hydrogen Bonding
The Journal of Physical Chemistry Letters, 2018Despite their importance in diverse chemical and biochemical processes, low-barrier hydrogen bonds remain elusive targets to classify and interpret spectroscopically. Here the correlated nature of hydrogen bonding and proton transfer in the low-barrier regime has been probed for the ground and excited electronic states of 6-hydroxy-2-formylfulvene by ...
Zachary N. Vealey +2 more
openaire +3 more sources
Unraveling Low‐Barrier Hydrogen Bonds in Complex Systems with a Simple Quantum Topological Criterion
Chemistry – A European Journal, 2011The importance of low-barrier hydrogen bonds (LBHBs) in enzyme catalysis has remained a controversial topic. LBHBs are defined as protons that are delocalized between two heavy atoms. Since the 1990s LBHBs have been proposed to play a crucial role in several enzyme-catalytic pathways by stabilizing transition states or reaction intermediates.
Chaudret, Robin +3 more
openaire +4 more sources
Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Enzymes
1998Acetylcholinesterase (AChE) and chymotrypsin are serine enzymes whose catalytic mechanism involves a nucleophilic attack (serine) and a general acid-base moiety (histidine). The incipient imidiazolium which is formed as a result of the nucleophilic attack by serine is stabilized by the negatively charged carboxylate (Glu or Asp).
Nathan A. Baker +4 more
openaire +2 more sources