Results 21 to 30 of about 84,757 (292)
Breaking the low barrier hydrogen bond in a serine protease [PDF]
Protein Science, 1999 AbstractThe serine protease subtilisin BPN' is a useful catalyst for peptide synthesis when dissolved in high concentrations of a water‐miscible organic co‐solvent such as N, N‐dimethylformamide (DMF). However, in 50% DMF, the kcat for amide hydrolysis is two orders of magnitude lower than in aqueous solution.
R D, Kidd +5 more
openaire +2 more sources
Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond [PDF]
, 2022 Here, we report a novel mechanism to selectively degrade target proteins. 3-(3-Phenoxybenzyl)amino-β-carboline (PAC), a tubulin inhibitor, promotes selective degradation of αβ-tubulin heterodimers.
Haoyu Ye (6588242) +14 more
core +1 more source
Molecular probe dynamics reveals suppression of ice-like regions in strongly confined supercooled water. [PDF]
PLoS ONE, 2012 The structure of the hydrogen bond network is a key element for understanding water's thermodynamic and kinetic anomalies. While ambient water is strongly believed to be a uniform, continuous hydrogen-bonded liquid, there is growing consensus that ...
Debamalya Banerjee +3 more
doaj +1 more source
Protonation Equilibrium in the Active Site of the Photoactive Yellow Protein
Molecules, 2021 The role and existence of low-barrier hydrogen bonds (LBHBs) in enzymatic and protein activity has been largely debated. An interesting case is that of the photoactive yellow protein (PYP).
Pablo Campomanes, Stefano Vanni
doaj +1 more source
Micro, 2023 In the present work, the intramolecular O-H···O hydrogen bonding in 3-hydroxy-1,3-diphenylprop-2-en-1-one (keto-enol form of dibenzoylmethane, DBM) was investigated.
Boris A. Kolesov +2 more
doaj +1 more source
Low-Barrier Hydrogen Bond between Phosphate and the Amide Group in Phosphopeptide [PDF]
, 2016 As the conversion between the monoionic (1) and diionic (2) form of the phosphate occurs, the phosphorylated peptides or proteins can not only cause the formation of a hydrogen bond between the phosphate group and the amide group but also change the ...
Kenji Kanazawa (1769257) +7 more
core +1 more source
Low-barrier hydrogen bonds in enzyme cooperativity
Nature, 2019 The underlying molecular mechanisms of cooperativity and allosteric regulation are well understood for many proteins, with haemoglobin and aspartate transcarbamoylase serving as prototypical examples1,2. The binding of effectors typically causes a structural transition of the protein that is propagated through signalling pathways to remote sites and ...
Dai, Shao-Bo +8 more
openaire +4 more sources
Hydrophobic Molecules Slow Down the Hydrogen-Bond Dynamics of Water [PDF]
, 2011 We study the spectral and orientational dynamics of HDO molecules in solutions of tertiary-butyl-alcohol (TBA), trimethyl-amine-oxide (TMAO), and tetramethylurea (TMU) in isotopically diluted water (HDO:D2O and HDO:H2O). The spectral dynamics are studied
Bakulin, Artem A. +15 more
core +1 more source
Proton-mediated photoprotection mechanism in photosystem II
Frontiers in Plant Science, 2022 Photo-induced charge separation, which is terminated by electron transfer from the primary quinone QA to the secondary quinone QB, provides the driving force for O2 evolution in photosystem II (PSII).
Yu Sugo +2 more
doaj +1 more source
The Shortest Symmetrical O−H···O Hydrogen Bond Has a Low-Barrier Double-Well Potential [PDF]
, 2016 The strong hydrogen bond, in which a hydrogen atom is centered between two electronegative atoms in a single minimum potential has been widely discussed but rarely definitively observed.
John A. Cowan (2700151) +8 more
core +1 more source