Results 31 to 40 of about 123,228 (263)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Identification of low cycle fatigue parameters

Applied and Computational Mechanics, 2009
The article describes a new approach to the processing of experimental data coming from low-cycle fatigue (LCF) tests. The data may be either tables from the standard tests, or a time series of loading processes and corresponding numbers of cycles to ...
Balda M.
doaj  

Assessment of Durability of the Toothed Segment Based on FEM Analysis and Low Fatigue Cycle Test

Archives of Foundry Engineering, 2016
The development of a novel design for the toothed segment of drive transmission in longwall shearer is expected to significantly reduce the cost of individual components of the feed system and the related work of repair and renovations, increasing at the
Piekło J., Maj M., Żuczek R., Pysz S.
doaj   +1 more source

Cumulative Damage in Very High/Low Cycle Combined Fatigue for TC21 Titanium Alloy

Crystals, 2022
The effect of low cycle fatigue (LCF) predamage with no precracks on very high cycle fatigue (VHCF) properties, and crack initiation characteristics for TC21 titanium alloy, was investigated.
Baohua Nie, Shuai Liu, Yue Wu, Yu Song, Haiying Qi, Binqing Shi, Zihua Zhao, Dongchu Chen   +7 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Study on high-low cycle fretting fatigue life of Inconel718 tenon structure

Hangkong gongcheng jinzhan
The turbine blades of aero-engines are subjected to cyclic high-low cycle loads in actual service environments，which is a typical high-low cycle micro motion fatigue condition. The frequent occurrence of fatigue fracture in turbine blades due to fretting
YANG Xiaolin, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Sensitivity analysis for effects of displacement amplitude and loading frequency on low-cycle fatigue lifetime in carbon/epoxy laminated composites

MATEC Web of Conferences, 2018
In the present article, the low-cycle fatigue lifetime of carbon/epoxy laminated composites has been investigated. The sensitivity analysis has been also performed to study effects of the displacement amplitude and the loading frequency on the low-cycle ...
Azadi Mohammad, Alizadeh Mohsen, Sayar Hassan   +2 more
doaj   +1 more source

Effect of Prolonged Thermal Exposure on Low-Cycle Bending Fatigue Resistance of Low-Carbon Steel

Metals, 2022
Using a dynamic mechanical analyzer, the comparative studies of a low-cycle bending fatigue were carried out for AISI 1022 low-carbon steel after extreme thermal exposure, simulating the severe beyond-design-basis accident at nuclear power plants. In the
Sergey A. Nikulin, Stanislav O. Rogachev, Vladislav A. Belov, Mikhail Y. Zadorozhnyy, Nikolay V. Shplis, Mikhail M. Skripalenko   +5 more
doaj   +1 more source

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato, Alessia Giugno, Miriam Sturniolo, Enrico Fratto, Pio Zoleo, Francesca Felicia Operto, Ilaria Sammarra, Antonio Gambardella   +7 more
wiley   +1 more source