Results 21 to 30 of about 1,184,339 (384)

HDL and plaque regression in a multiphase model of early atherosclerosis [PDF]

, 2023
Atherosclerotic plaques are accumulations of cholesterol-engorged macrophages in the artery wall. Plaque growth is initiated and sustained by the deposition of low density lipoproteins (LDL) in the artery wall. High density lipoproteins (HDL) counterbalance the effects of LDL by accepting cholesterol from macrophages and removing it from the plaque. In
arxiv   +1 more source

Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein [PDF]

Biochemical Journal, 1996
The oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis, although little is known as yet about the precise mechanism of oxidation in vivo. The studies presented here demonstrate that, in the absence of cells or transition metals, oxidized LDL can modify native LDL through co-incubation in ...
David S. Leake, Min Yang, Catherine Rice-Evans   +2 more
openaire   +3 more sources

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.

Proceedings of the National Academy of Sciences of the United States of America, 1979
Resident mouse peritoneal macrophages were shown to take up and degrade acetylated (125)I-labeled low density lipoprotein ((125)I-acetyl-LDL) in vitro at rates that were 20-fold greater than those for the uptake and degradation of (125)I-LDL.
J. Goldstein, Y. K. Ho, S. Basu, Michael S. Brown   +3 more
semanticscholar   +1 more source

Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases

Oxidative Medicine and Cellular Longevity, 2017
Low-density lipoprotein (LDL) plays a key role in the development and progression of atherosclerosis and cardiovascular disease. LDL consists of several subclasses of particles with different sizes and densities, including large buoyant (lb) and ...
E. Ivanova, V. Myasoedova, A. Melnichenko, A. Grechko, A. Orekhov   +4 more
semanticscholar   +1 more source

Low density lipoproteins in atherosclerosis.

Journal of Lipid Research, 1988
Low density lipoproteins (LDL) have long been implicated in the development of atherosclerosis. Perhaps the most convincing evidence that these lipoproteins are causative factors in this disease is the genetic disorder, familial hypercholesterolemia, in which homozygous patients develop massive LDL concentrations and frequently die within the second ...
John S. Parks, Lawrence L. Rudel, Fred L. Johnson, J Babiak   +3 more
openaire   +4 more sources

Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis

British medical journal, 2003
Objectives To determine by how much statins reduce serum concentrations of low density lipoprotein (LDL) cholesterol and incidence of ischaemic heart disease (IHD) events and stroke, according to drug, dose, and duration of treatment.
M. Law, N. Wald, A. Rudnicka
semanticscholar   +1 more source

Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting

European Heart Journal, 2018
Aims Lipoprotein(a) (Lp(a)) elevation is a causal risk factor for cardiovascular disease (CVD). It has however been suggested that elevated Lp(a) causes CVD mainly in individuals with high low-density lipoprotein cholesterol (LDL-C) levels.
R. Verbeek, Renate M. Hoogeveen, A. Langsted, Lotte C. A. Stiekema, S. Verweij, G. Hovingh, N. Wareham, K. Khaw, S. Boekholdt, B. Nordestgaard, E. Stroes   +10 more
semanticscholar   +1 more source

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

Scientific Reports, 2016
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging.
Barbara W. Sódar, Á. Kittel, K. Pálóczi, Krisztina V. Vukman, X. Osteikoetxea, K. Szabó-Taylor, A. Németh, B. Sperlágh, T. Baranyai, Z. Giricz, Z. Wiener, Lilla Turiák, L. Drahos, É. Pállinger, K. Vékey, P. Ferdinandy, A. Falus, E. Buzás   +17 more
semanticscholar   +1 more source

Low-Density Lipoprotein Receptors

, 1991
The origins of the receptor theory are based on the work of Paul Ehrlich (1854–1915) and John Newport Langley (1852–1925) (Parascandola 1981), who were the first to postulate that specific cellular reactions to drugs must be based on so-called receptive substances.
Niendorf, A., Beisiegel, Ulrike, Seifert, G.   +2 more
openaire   +4 more sources

Low density lipoprotein misfolding and amyloidogenesis

The FASEB Journal, 2008
In early atherogenesis, subendothelial retention of lipidic droplets is associated with an inflammatory response-to-injury, culminating in the formation of foam cells and plaque. Low density lipoprotein (LDL) is the main constituent of subendothelial lipidic droplets. The process is believed to occur following LDL modification. Searching for a modified
Parasassi, T., De Spirito, Marco, Mei, G., Brunelli, R., Greco, G., Lenzi, L., Maulucci, Giuseppe, Nicolai, E., Papi, Massimiliano, Arcovito, G., Tosatto, S. C. E., Ursini, F.   +11 more
openaire   +7 more sources