Results 31 to 40 of about 10,975,472 (295)

Metabolic origins and clinical significance of LDL heterogeneity

Journal of Lipid Research, 2002
LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL ...
Kaspar K. Berneis, Ronald M. Krauss
doaj   +1 more source

Low-density lipoprotein particles in atherosclerosis

Frontiers in Physiology, 2022
Among the diseases causing human death, cardiovascular disease (CVD) remains number one according to the World Health Organization report in 2021. It is known that atherosclerosis is the pathological basis of CVD.
Ya-Nan Qiao, Yan-Li Zou, Shou-Dong Guo
doaj   +1 more source

The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis[S]

Journal of Lipid Research, 2015
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI–DV) with disparate structures
Yu-Xin Xu, David Ashline, Li Liu, Carlos Tassa, Stanley Y. Shaw, Katya Ravid, Matthew D. Layne, Vernon Reinhold, Phillips W. Robbins   +8 more
doaj   +1 more source

Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein [PDF]

Biochemical Journal, 1996
The oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis, although little is known as yet about the precise mechanism of oxidation in vivo. The studies presented here demonstrate that, in the absence of cells or transition metals, oxidized LDL can modify native LDL through co-incubation in ...
M, Yang, D S, Leake, C A, Rice-Evans
openaire   +2 more sources

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

Journal of Lipid Research, 2007
The reduction of cardiovascular mortality associated with moderate alcohol consumption is chiefly thought to be mediated by an increase of high density lipoprotein cholesterol (HDL-CH).
Christian Schäfer, Alexandr Parlesak, Joachim Eckoldt, Christiane Bode, Johann Christian Bode, Winfried März, Karl Winkler   +6 more
doaj   +1 more source

Low density lipoprotein misfolding and amyloidogenesis

The FASEB Journal, 2008
ABSTRACT In early atherogenesis, subendothelial retention of lipidic droplets is associated with an inflammatory response‐to‐injury, culminating in the formation of foam cells and plaque. Low density lipoprotein (LDL) is the main constituent of subendothelial lipidic droplets.
Parasassi, T., De Spirito, Marco, Mei, G., Brunelli, R., Greco, G., Lenzi, L., Maulucci, Giuseppe, Nicolai, E., Papi, Massimiliano, Arcovito, G., Tosatto, S. C. E., Ursini, F.   +11 more
openaire   +7 more sources

Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I.

Journal of Lipid Research, 1990
We have shown previously that low density lipoprotein (LDL) subjected to vortexing forms self-aggregates that are avidly phagocytosed by macrophages. That phagocytic uptake is mediated by the LDL receptor.
JC Khoo, E Miller, P McLoughlin, D Steinberg   +3 more
doaj   +1 more source

Low-Density Lipoprotein Receptors

, 1991
The origins of the receptor theory are based on the work of Paul Ehrlich (1854–1915) and John Newport Langley (1852–1925) (Parascandola 1981), who were the first to postulate that specific cellular reactions to drugs must be based on so-called receptive substances.
Niendorf, A., Beisiegel, Ulrike, Seifert, G.   +2 more
openaire   +3 more sources

Italian Multicenter Study on Low-Density Lipoprotein Apheresis Working Group 2009 Survey

, 2013
We present results of the second survey of the Italian Multicenter Study on Low-Density Lipoprotein Apheresis (IMSLDLa-WG/2). The study involved 18 centers in 2009, treating 66 males and 35 females, mean age 47 +/- 18 years.
MOROZZI, CLAUDIA, STEFANUTTI, Claudia, DI GIACOMO, SERAFINA, The Italian Multicenter Study O. N. Low Density Lipoprotein Apheresis Working Group   +3 more
core   +1 more source

LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans

Journal of Lipid Research, 2015
The mechanisms by which LDLs and HDLs cross the vascular endothelium from plasma into interstitial fluid are not understood, and have never been studied in humans in vivo.
C. Charles Michel, M. Nazeem Nanjee, Waldemar L. Olszewski, Norman E. Miller   +3 more
doaj   +1 more source