Results 41 to 50 of about 320,078 (208)

Uptake of synthetic low density lipoprotein by leukemic stem cells — a potential stem cell targeted drug delivery strategy [PDF]

, 2010
Chronic Myeloid Leukemia (CML) stem/progenitor cells, which over-express Bcr-Abl, respond to imatinib by a reversible block in proliferation without significant apoptosis.
Jørgensen, Heather G., Jorgensen, Heather G., Tessa L. Holyoake, Heather G. Jørgensen, Scobie, Linda; id_orcid, Elliott, Moira A., Scobie, Linda, Crossan, Claire, Hatziieremia, Sophia, Zhou, Peixun; id_orcid, Elliott, Moira A, Sophia Hatziieremia, Michie, Alison M, Holyoake, Tessa L., Holyoake, Tessa L, Jørgensen, Heather G, Alison M. Michie, Halbert, Gavin W., Linda Scobie, Gavin W. Halbert, Moira A. Elliott, Claire Crossan, Michie, Alison M., Peixun Zhou, Halbert, Gavin W, Zhou, Peixun   +25 more
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Underestimation of Low Density Lipoprotein-Cholesterol With the Friedewald Equation Versus a Direct Homogenous Low Density Lipoprotein-Cholesterol Assay [PDF]

Laboratory Medicine, 2017
Low-density lipoprotein cholesterol (LDL-C) concentrations are the primary therapeutic target in patients with atherosclerotic cardiovascular disease (ASCVD). However, at low LDL-C concentrations, there is a significant underestimation using the Friedewald equation compared with ultracentrifugation.In this pilot study, we compared LDL-C concentrations ...
Ishwarlal, Jialal, Michael, Inn, David, Siegel, Sridevi, Devaraj   +3 more
openaire   +2 more sources

The tangled web of dyslipidemia and cancer: Is there any association?

Journal of Research in Medical Sciences, 2022
Cancer is a primary cause of mortality around the world and imposes a significant physiological, psychological, and financial burden on patients. Lipids regulate cell cycle progression and affect cell proliferation, migration, and apoptosis.
Sina Neshat, Abbas Rezaei, Armita Farid, Rojin Sarallah, Salar Javanshir, Sarina Ahmadian, Gelayol Chatrnour, Padideh Daneii, Kiyan Heshmat-Ghahdarijani   +8 more
doaj   +1 more source

Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol

Journal of Cardiovascular Pharmacology and Therapeutics, 2005
A high concentration of low-density lipoprotein cholesterol (LDL-C) in plasma is one of the strongest risk factors for atherosclerotic cardiovascular disease and mortality. The most common approach to determining LDL-C in the clinical laboratory is the Friedewald calculation.
Bairaktari, E. T., Seferiadis, K. I., Elisaf, M. S.   +2 more
openaire   +3 more sources

Insights Into PCSK9, Low-Density Lipoprotein Receptor, and Low-Density Lipoprotein Cholesterol Metabolism [PDF]

Circulation, 2013
The identification of PCSK9 in 20031 has resulted in substantial revision to previous knowledge regarding cholesterol homeostasis, provided new insights into low-density lipoprotein (LDL) metabolism and LDL receptor (LDLR) function, and presented a new compelling therapeutic target to reduce LDL cholesterol (LDL-C). PCSK9 is a serine protease expressed
Evan A, Stein, Frederick J, Raal
openaire   +2 more sources

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans [PDF]

, 1997
Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown.
de Roos, B, Tol, Aad, de Roos, B., de Jong-Caesar, R., Scheek, L.M., Urgert, R., Scheek, L. M., Gent, T, Caesar, R (Ruth), Gent, T. van, Katan, MB, Roos, B. de, van Tol, A., Jong-Caesar, R. de, van Gent, T., Tol, A. van, Scheek, LM (Leo), Urgert, R, Katan, M.B.; id_orcid, Katan, M.B.   +19 more
core   +1 more source

Assessment of serum lipids in pregnant women aged over 35 years and their relation with pre-eclampsia [PDF]

Einstein (São Paulo), 2008
Objective: To assess serum total cholesterol, low density lipoproteincholesterol, high density lipoprotein cholesterol, very low densitylipoprotein cholesterol and triglyceride levels in pregnant womenaged over 35 years during the first and second ...
Umberto Gazi Lippi, Sidney Antonio Lagrosa Garcia, Reginaldo Guedes Coelho Lopes, Marcos Yorghi Khoury, Winny Hirome Takahashi, Silvio Martinelli   +5 more
doaj  

Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low‐Density Lipoprotein Cholesterol or Non‐High‐Density Lipoprotein Cholesterol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundHigher concentrations of the apolipoprotein B (apoB) lipoproteins increase the risk of cardiovascular disease. However, whether the risk associated with apoB lipoproteins varies with age has not been well examined.
Allan D. Sniderman, Shofiqul Islam, Matthew McQueen, Michael Pencina, Curt D. Furberg, George Thanassoulis, Salim Yusuf   +6 more
doaj   +1 more source

Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy.

, 2009
OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.
Prasad, A, McConnell, JP, Ford, MA, Lavi, S, Sandhu, GS, Rihal, CS, Lerman, LO, Lerman, A, Hartman, SJ   +8 more
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Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency [PDF]

, 2009
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease)
Low, J K, Low, J.K.
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