IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Near-Infrared and Red-Light Photobiomodulation for Ocular Aging and Diseases: A Narrative Review
Ophthalmology and TherapyNear-infrared (NIR) and red light photobiomodulation (PBM) has gained increasing interest as a non-invasive therapeutic approach for a variety of medical conditions including ocular diseases.
Ethan Waisberg +9 more
doaj +1 more source
Low level light therapy/photobiomodulation for diabetic peripheral neuropathy: protocol of a systematic review and meta-analysis. [PDF]
BMJ Open, 2022 Wang JY +7 more
europepmc +1 more source
The Efficacy of Low-Level Laser Therapy for Pain Modulation
, 2018 Low level laser therapy is a modality that uses specific wavelengths of light to aid the treatment of a variety of musculoskeletal disorders. One use for low level laser therapy is pain modulation.
Anderson, Christine +3 more
core
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Effect of Low-level Light Therapy on Idiopathic Facial Paralysis Recovery: A Narrative Review
Journal of Acupuncture ResearchThis study was conducted to summarize and provide direction for the current use of low-level light therapy (LLLT) for the treatment of idiopathic facial nerve palsy.
Jihoon Kong +6 more
doaj +1 more source
A randomized controlled study evaluating outcomes of intense pulsed light and low-level light therapy for treating meibomian gland dysfunction and evaporative dry eye. [PDF]
Indian J Ophthalmol, 2023 D'Souza S +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Efficacy and safety of skin-adhesive low-level light therapy for overactive bladder: a Phase III study. [PDF]
Int Urogynecol J, 2022 Hwang WY +5 more
europepmc +1 more source