Results 151 to 160 of about 1,276,396 (292)

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Effect of Low-level Light Therapy on Idiopathic Facial Paralysis Recovery: A Narrative Review

open access: yesJournal of Acupuncture Research
This study was conducted to summarize and provide direction for the current use of low-level light therapy (LLLT) for the treatment of idiopathic facial nerve palsy.
Jihoon Kong   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren's Syndrome. [PDF]

open access: yesJ Ophthalmol, 2021
Di Marino M   +9 more
europepmc   +1 more source

Treatment of Alopecia with Low-Level Light Therapy

open access: yesSKIN The Journal of Cutaneous Medicine
Low-level light therapy (LLLT) is a safe, non-invasive treatment for various alopecias, offering an alternative or adjunct to pharmacologic therapies. By using specific wavelengths, LLLT releases nitric acid, increases blood flow, inhibits DHT, stimulates follicular cells, enhances mitochondrial activity, and modulates inflammatory pathways.
Aysham Chaudry   +5 more
openaire   +1 more source

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