Results 111 to 120 of about 13,997,719 (325)

Fano symmetric varieties with low rank

, 2010
The symmetric projective varieties of rank one are all smooth and Fano by a classic result of Akhiezer. We classify the locally factorial (respectively smooth) projective symmetric $G$-varieties of rank 2 which are Fano.
Ruzzi, Alessandro
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Low-Rank Quantum State Preparation

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Ubiquitous in quantum computing is the step to encode data into a quantum state. This process is called quantum state preparation, and its complexity for non-structured data is exponential on the number of qubits. Several works address this problem, for instance, by using variational methods that train a fixed depth circuit with manageable complexity ...
Israel F. Araujo, Carsten Blank, Ismael C. S. Araújo, Adenilton J. da Silva   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

FouRA: Fourier Low-Rank Adaptation

Advances in Neural Information Processing Systems 37
While Low-Rank Adaptation (LoRA) has proven beneficial for efficiently fine-tuning large models, LoRA fine-tuned text-to-image diffusion models lack diversity in the generated images, as the model tends to copy data from the observed training samples. This effect becomes more pronounced at higher values of adapter strength and for adapters with higher ...
Borse, Shubhankar, Kadambi, Shreya, Pandey, Nilesh Prasad, Bhardwaj, Kartikeya, Ganapathy, Viswanath, Priyadarshi, Sweta, Garrepalli, Risheek, Esteves, Rafael, Hayat, Munawar, Porikli, Fatih   +9 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Online Learning with Low Rank Experts

, 2016
We consider the problem of prediction with expert advice when the losses of the experts have low-dimensional structure: they are restricted to an unknown $d$-dimensional subspace. We devise algorithms with regret bounds that are independent of the number
Hazan, Elad, Koren, Tomer, Livni, Roi, Mansour, Yishay   +3 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Combined subspace low rank learning and nonlocal low rank estimation for spectral super-resolution of multispectral remote sensing images

International Journal of Digital Earth
Spectral Super-Resolution (SR) of Multispectral Images (MSI) enhances spectral resolution in MSI's non-overlapping regions by utilizing the overlapping regions with Hyperspectral Images (HSI).
Jun Zhou, Weiwei Sun, Xiangchao Meng, Gang Yang, Binjie Chen, Kai Ren   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source