Results 121 to 130 of about 83,095 (256)

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

A Study on the Clinical Application of Greater Omental Pedicle Flap Transplantation to Correct Anterior Resection Syndrome in Patients With Low Rectal Cancer [PDF]

, 2020
Haiquan Qin, Linghou Meng, Zigao Huang, Jiankun Liao, Yan Feng, Shanshan Luo, Hao Lai, Weizhong Tang, Xianwei Mo   +8 more
openalex   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome

Videosurgery and Other Miniinvasive Techniques, 2018
Michał M. Nowakowski, Mateusz Rubinkiewicz, Natalia Gajewska, Grzegorz Torbicz, Michał Wysocki, Piotr Małczak, Piotr Major, Mateusz Wierdak, Andrzej Budzyński, Michał Pędziwiatr   +9 more
doaj   +1 more source

Clinical and manometric findings before and after low anterior resection: patients with rectal cancer

Iranian South Medical Journal, 2009
Background: Low anterior rectal resection is an option for low rectal cancer. The aim of this study was to assess the clinical and manometric findings before and after low anterior resection in patients with rectal cancer.
Mohammad sadegh Fazeli, Farrokh kamran khajavi, Seyed Mehdi Jalali, Ramesh Omrani pour   +3 more
doaj  

INFLUENCE OF DEFUNCTIONING COLOSTOMY AFTER LOW ANTERIOR RESECTION FOR RECTAL CANCER ON EARLY POSTOPERATIVE PERIOD

, 2017
D. V. Zitta, В. М. Субботин
openalex   +2 more sources

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Effectiveness of transanal irrigation in low anterior resection syndrome. [PDF]

Colorectal Dis
Jauhari S, Hopkinson-Woolley D, Curran K, Doyle R, Boffin H, Gorissen K, Singh S.   +6 more
europepmc   +1 more source

Defunctioning Ileostomy After Low Anterior Resection of Rectum: Morbidity Related to Fashioning and Closure [PDF]

Nikolaos Gouvas, Dimitrios K. Manatakis, Christos Agalianos, Nikoletta Dimitriou, Ioannis Baloyiannis, George Tzovaras, Evangelos Xynos   +6 more
openalex   +1 more source