Results 131 to 140 of about 83,095 (256)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Low anterior resection syndrome - what's the urgency? [PDF]

ANZ J Surg
Wilson K, Solomon M, Cornish JA, Quyn A, Croft J, Stevenson A, Warwick AM, Ng KS.   +7 more
europepmc   +1 more source

Massive lower gastrointestinal bleeding after low anterior resection for middle rectal cancer – case report

, 2015
Mircea Beuran, Ionuț Negoi, Sorin Păun, Valentina Madalina Negoita, Bogdan Stoica, I Tănase, Mihaela Vartic, Ruxandra Irina Negoi, Sorin Hostiuc   +8 more
openalex   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Randomized clinical trial of high versus low inferior mesenteric artery ligation during anterior resection for rectal cancer [PDF]

, 2018
Shoichi Fujii, Atsushi Ishibe, Masayuki Ota, Kazuteru Watanabe, Jun Watanabe, Chikara Kunisaki, Itaru Endo   +6 more
openalex   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Prevalence and clinical significance of evacuation disorders in patients with low anterior resection syndrome. [PDF]

Ann Coloproctol
Homma Y, Mimura T, Koinuma K, Horie H, Sata N.   +4 more
europepmc   +1 more source

3. Surgical Therapy for Colorectal Cancer-Surgical Removal of Hepatic Metastasis and Low Anterior Resection of Rectal Cancer

, 2007
Tsuneo Iiai, Tatsuo Tani, Satoshi Maruyama, Yoshio Shirai, Katsuyoshi Hatakeyama   +4 more
openalex   +2 more sources

Risk factors for anastomotic leakage after laparoscopic low anterior resection with DST anastomosis [PDF]

, 2014
Kenji Kawada, Suguru Hasegawa, Koya Hida, Kenjiro Hirai, Kae Okoshi, Akinari Nomura, Junichiro Kawamura, Satoshi Nagayama, Yoshiharu Sakai   +8 more
openalex   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source