Results 61 to 70 of about 10,131,417 (246)

Relationships between Anxiety, Depression, Low Anterior Resection Syndrome, and Quality of Life Following Lower Anterior Resection for Rectal Cancer [PDF]

, 2014
Purpose: The purpose of this study was to investigate the relationships between anxiety, depression, low anterior resection syndrome, and quality of life after lower anterior resection for rectal cancer.
이은, 김금순
core  

Rectal Reconstruction after Total Mesorectumectomy: Functional Outcomes and Quality of Life

Креативная хирургия и онкология, 2021
Background. The study aims to compare the functional outcomes and quality of life in patients having variant rectal reconstruction procedures after low anterior resection for cancer.Materials and methods.
A. O. Rasulov, A. B. Baychorov, A. M. Merzlyakova, A. I. Ovchinnikova, A. V. Semyanikhina   +4 more
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Ondansetron for Low Anterior Resection Syndrome (LARS)

, 2023
The aim of the study was to examine the efficacity and safety of ondansetron, a serotonin receptor antagonist, to treat patients with low anterior resection syndrome (LARS). LARS after rectal resection is common and debilitating.
Raffaello Roesel, Galafassi, J., Seraina Faes, di Tor Vajana, A.F., Christoforidis, D., Sotirios Georgios Popeskou, Vanoni, A., Faes, S., Popeskou, S.G., Dimitri Christoforidis, Jacopo Galafassi, Alice Vanoni, Antonjacopo Ferrario di Tor Vajana, Piotet, L.M., Roesel, R., Laure-Meline Piotet   +15 more
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Case Report: Sufficient pelvic floor muscle function can retain acceptable postoperative defecation function after in-situ anal reconstruction surgery in patients with ultra-low rectal/anal cancer

Frontiers in Surgery
BackgroundPatients with ultra-low rectal cancer/anal canal cancer generally undergo abdominoperineal resection with sigmoid colostomy. Patients commonly experience poor quality of life postoperatively, often feeling that their dignity is compromised ...
Li Lin, Yihui Lei, Yihui Lei, Guoyan Liu, Guoyan Liu, Guoyan Liu   +5 more
doaj   +1 more source

Redefining Low Anterior Resection Syndrome

, 2021
Low Anterior Resection Syndrome (LARS) is used to describe bowel dysfunction which patients experience after rectal cancer treatment. There is interest in the field as the accumulating evidence reinforces that LARS is common.
Keane, Celia
core  

Low Anterior Resection Syndrome After Transanal Total Mesorectal Excision: A Comparison With the Conventional Top-to-Bottom Approach

, 2020
BACKGROUND: Advances in sphincter saving procedures improved the quality of life of patients with rectal cancer. However, many of them suffered from functional disturbance after surgery, including the low anterior resection syndrome.
Julian S. Tsang, Wai Lun Law, Ka Kin Ng, Tsang, J, Rockson Wei, Law, WL, Yip, J, Chi Chung Foo, Lo, OSH, Foo, CC, Ng, KK, Jeremy Yip, Wei, R, Oswens Siu-hung Lo   +13 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source