Results 21 to 30 of about 10,906,631 (237)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Short overview on guidelines for low back pain: LBP (low back pain guidelines) [PDF]

Serbian Journal of Anesthesia and Intensive Therapy
Low back pain occurs in the area of the back between the lower edge of the 12th rib and the lower edge of the gluteus, with or without spreading down the leg. LBP occurs as a result of a combination of the influence of various physical, psychological and
Lađević Nebojša G., Jovičić Jelena, Petrović Nataša, Jovanović Vesna, Lazić Miloš, Srećković Svetlana, Lađević Nikola N., Dimić Nemanja, Šipetić Grujičić Sandra   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Short-Term Effects of NO₂ Exposure on Hospitalization for Chronic Kidney Disease

Toxics
This study investigates the correlation between short-term exposure to nitrogen dioxide (NO2) and hospitalization for chronic kidney disease (CKD) in Lanzhou, China.
Wancheng Zhang, Ye Ruan, Jianglong Ling
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Discogenic low back pain : lumbar spondylodesis revisited [PDF]

, 2000
Neurosurgeon deals with chronic low back pain patients almost daily. Most of these patients still have complaints of low back pain despite many different previous therapies.
Coppes, Maarten Hubert,, Coppes, Maarten Hubert   +1 more
core   +14 more sources

In silico analysis on sacroiliac joint fixation during normal walking

Journal of Biomechanical Science and Engineering
According to medical statistics, sacroiliac joints (SIJs) appear to be the source of low back pain in 15 - 30% of cases. The SIJs are located at the junction between the sacrum and the ilium, supported by strong ligaments and with low mobility.
Ryota TOYOHARA, Daisuke KUROSAWA, Niels HAMMER, Toshiro OHASHI   +3 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Low back pain and risk factors for low back pain in car drivers

, 2008
The cause of low back pain in populations of professional drivers is uncertain. A literature review revealed factors that seem to be associated with low back pain (e.g.
Gallais, Lenka
core   +1 more source