Results 31 to 40 of about 1,256,344 (293)

Short-Term Effects of NO₂ Exposure on Hospitalization for Chronic Kidney Disease

Toxics
This study investigates the correlation between short-term exposure to nitrogen dioxide (NO2) and hospitalization for chronic kidney disease (CKD) in Lanzhou, China.
Wancheng Zhang, Ye Ruan, Jianglong Ling
doaj   +1 more source

Degeneration of the intervertebral disc with new approaches for treating low back pain. [PDF]

, 2015
This review paper discusses the process of disc degeneration and the current understanding of cellular degradation in patients who present with low back pain.
Binch, AL, Hughes, SP, Le Maitre, CL, Thorpe, AA   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

In silico analysis on sacroiliac joint fixation during normal walking

Journal of Biomechanical Science and Engineering
According to medical statistics, sacroiliac joints (SIJs) appear to be the source of low back pain in 15 - 30% of cases. The SIJs are located at the junction between the sacrum and the ilium, supported by strong ligaments and with low mobility.
Ryota TOYOHARA, Daisuke KUROSAWA, Niels HAMMER, Toshiro OHASHI   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Short term effects of changes in air pollutant concentrations during peaks traffic hours on hospitalization for respiratory diseases

Scientific Reports
Research on the impact of changes in air pollutant concentrations during peak traffic hours on hospital admissions for respiratory diseases (RD) is limited. This study utilized a distributed lag nonlinear model (DLNM) to investigate this effect.
Wancheng Zhang, Ye Ruan, Jianglong Ling
doaj   +1 more source

Proprioception and Geriatric Low Back Pain

Spine Surgery and Related Research, 2022
Proprioception is a deep sensation that perceives the position of each part of the body, state of movement and muscle contraction, and resistance and mass applied to the body. Proprioceptive feedback influences movement and positional accuracy, resulting
Yoshihito Sakai, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Naoaki Osada, Takaya Sugiura, Yoshifumi Morita, Keitaro Kawai, Tadashi Ito, Kazunori Yamazaki   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A study of the correlation between meteorological factors and hospitalization for acute lower respiratory infections in children

BMC Public Health
Background The study focuses on the effect of temperature and relative humidity on hospitalization for acute lower respiratory tract infections (LRTI) in children, respectively.
Wancheng Zhang, Ye Ruan, Jianglong Ling, Lei Wang   +3 more
doaj   +1 more source