Results 51 to 60 of about 813,093 (318)

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

A study of the correlation between urinary perchlorate, nitrate, thiocyanate, and serum liver function indices

Scientific Reports
This study explored relationship between concentrations of perchlorate, nitrate, and thiocyanate and serum liver function markers using data from 3366 adults in the 2013–2018 National Health and Nutrition Examination Survey (NHANES) of the United States.
Wancheng Zhang, Jianglong Ling, Lixiu Lan, Qiuhong Guo, Ye Ruan, Dingchang Wu   +5 more
doaj   +1 more source

Domains of Chronic Low Back Pain and Assessing Treatment Effectiveness: A Clinical Perspective

Pain Practice, 2019
Nonspecific chronic low back pain (CLBP) is a common clinical condition that has impacts at both the individual and societal level. Pain intensity is a primary outcome used in clinical practice to quantify the severity of CLBP and the efficacy of its ...
S. Tagliaferri, C. Miller, Patrick J Owen, Ulrike H. Mitchell, Helena Brisby, B. Fitzgibbon, H. Massé-Alarie, J. Van Oosterwijck, D. Belavy   +8 more
semanticscholar   +1 more source

Lived and Care Experiences of Chronic Musculoskeletal Shoulder Pain in Australian Adults: A Qualitative Study

Arthritis Care &Research, EarlyView.
Objective Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centered care and informing local service pathways and care guidelines or standards.
Sonia Ranelli, Joanne E. Jordan, Ilana N. Ackerman, Alison Thorpe, Jennifer G. Persaud, Linda J. Woodhouse, Jason Chua, Ben Horgan, Andrew M. Briggs   +8 more
wiley   +1 more source

Evaluating Low Back Pain Patients for Prolapsed Interverbral Disc in a Kenyan Teaching Hospital

The Annals of African Surgery, 2011
Background Accurate evaluation of low back pain is essential for its rational manage-ment. The extent of use of clinical and imaging findings in identification of prolapsed intervertebral disk varies between centers. In Kenya, the diagnostic procedure
Ongeti K, BSc, MBChB, Ogeng’o J
doaj  

Improvements in Health‐Related Quality of Life With Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post Hoc Analysis of a Randomized Multicenter Trial

Arthritis Care &Research, EarlyView.
Objective Although treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL ...
Austin Barry, Bryant R. England, Harlan Sayles, Lindsay N. Helget, Maria Androsenko, Hongsheng Wu, Kaleb Michaud, Bridget Kramer, Jeff A. Newcomb, Mary T. Brophy, Anne Davis‐Karim, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Paul M. Palevsky, James R. O'Dell, Ted R. Mikuls   +16 more
wiley   +1 more source

Chronic Low Back Pain: History, Symptoms, Pain Mechanisms, and Treatment

Life
Chronic low back pain (cLBP) is the most frequently reported cause of years lived with disability. Identifying the anatomical structures or dysfunction contributing to patients’ symptoms is critical to guiding treatment.
Tyler Farley, Jesse Stokke, Kush Goyal, Russell DeMicco   +3 more
doaj   +1 more source

The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain

Pain, 2018
Changes in central pain processing have been shown in patients with chronic low-back pain (cLBP). We used quantitative sensory testing methods to identify differences in pain sensitization between patients with cLBP (N = 167) and healthy controls (N = 33)
Samantha M. Meints, I. Mawla, V. Napadow, J. Kong, J. Gerber, Suk-tak Chan, A. Wasan, T. Kaptchuk, Christina McDonnell, J. Carriere, B. Rosen, R. Gollub, R. Edwards   +12 more
semanticscholar   +1 more source

Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration

Arthritis Care &Research, EarlyView.
Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed long‐term opioids over time.
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Tuhina Neogi, James R. O'Dell, Joshua F. Baker, Ted R. Mikuls   +7 more
wiley   +1 more source

Low back pain

Bulletin of the World Health Organization, 2003
Low back pain is a leading cause of disability. It occurs in similar proportions in all cultures, interferes with quality of life and work performance, and is the most common reason for medical consultations.
Ehrlich George E.
doaj