Results 41 to 50 of about 852 (212)

Low Cost Carriers and Foreign Tourism Inflows: a Cointegrated VAR Analysis for Italy

open access: yesAlmatourism, 2014
This paper seeks to quantify the impact of the expansion of LCC on foreign tourism trends in Italy. We rely on a novel data set on the seats on flights by low cost carriers between foreign destinations and each Italian airport.
Valter Di Giacinto, Andrea Migliardi
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Airline routes and second home tourism. The French market in the Algarve [PDF]

open access: yesJournal of Spatial and Organizational Dynamics, 2018
The new routes and services provided by low cost carriers enable the emergence of new tourist destinations in Europe and the development of new market segments that value the cheap and easy air accessibilities.
Cláudia Ribeiro Almeida
doaj  

Low-Cost Carriers in Aviation: Significance and Developments

open access: yesCoRR
This paper aims to discuss the impacts of low-cost airlines on the air transport market and, in particular, to present the most recent findings from the specialized literature in this field. To this end, several papers published on the topic since 2015 were selected and analyzed.
Oliveira, Alessandro V. M.   +1 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Impact of US Low Cost Carriers Entrance to the Airline Market in Colombia, South America

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2017
This study researched the impact of US low cost carriers’ entrance to the airline market in Colombia, South America. The study analyzed the overall market share between Florida and Colombia after U.S.
Carolina Anderson   +4 more
doaj   +1 more source

Surface‐Functionalizable Plant‐Derived Extracellular Vesicles for Targeted Drug Delivery Carrier Using Grapefruit

open access: yesAdvanced Materials Interfaces, 2023
Recently, membrane‐modified mammalian exosomes have been considered strong candidates for targeted drug delivery carriers because of their biocompatibility, biodistribution, and low immune response.
Kyunghwan Moon   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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