Results 51 to 60 of about 111,069 (305)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

An evaluation of the provision of terminal facilities for the design of low cost airport terminals [PDF]

, 2009
The growth of the Low Cost Carriers (LCCs) in the world will have a significant impact on future airport development. LCCs such as Ryanair, Air Asia and EasyJet prefer only basic terminal facilities (TFs) at Low Cost Terminals (LCTs) to reduce ...
Sabar, Rohafiz
core  

Impacts of low-cost carriers' development in the Asia-Pacific region on tourism, economic and social wellbeing: A systemic review [PDF]

This review undertook a systematic examination of 82 journal articles, focused on identifying the impacts of low-cost carriers in the Asia-Pacific region on tourism, economic development, and social wellbeing. The analysis determined that the development
Wang, Huan, Fu, Xiaowen, Kille, Tarryn, Tsui, Kan Wai Hong, Wu, Hanjun   +4 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Low Cost Carriers and Foreign Tourism Inflows: a Cointegrated VAR Analysis for Italy

Almatourism, 2014
This paper seeks to quantify the impact of the expansion of LCC on foreign tourism trends in Italy. We rely on a novel data set on the seats on flights by low cost carriers between foreign destinations and each Italian airport.
Valter Di Giacinto, Andrea Migliardi
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Airline routes and second home tourism. The French market in the Algarve [PDF]

Journal of Spatial and Organizational Dynamics, 2018
The new routes and services provided by low cost carriers enable the emergence of new tourist destinations in Europe and the development of new market segments that value the cheap and easy air accessibilities.
Cláudia Ribeiro Almeida
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Low-Cost Carriers in Aviation: Significance and Developments

CoRR
This paper aims to discuss the impacts of low-cost airlines on the air transport market and, in particular, to present the most recent findings from the specialized literature in this field. To this end, several papers published on the topic since 2015 were selected and analyzed.
Oliveira, Alessandro V. M., Oliveira, Bruno Felipe de   +1 more
openaire   +3 more sources

The impact of low-cost airline operations to Malta

, 2010
In 2006 the controversial step was undertaken by the Maltese government to provide incentives for new routes with the intention of attracting low cost carriers to fly to the Islands.
Graham, A., Dennis, N.
core   +1 more source