Results 81 to 90 of about 585,583 (302)

Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria

Journal of Lipid Research, 2004
The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production.
Tom Sprong, Mihai G. Netea, Peter van der Ley, Trees J.G. Verver-Jansen, Liesbeth E.H. Jacobs, Anton Stalenhoef, Jos W.M. van der Meer, Marcel van Deuren   +7 more
doaj   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins

Journal of Lipid Research, 2002
Small, dense LDL particles are typical for FCHL. Intravascular lipid exchange and net transfer among HDL, LDL, and triglyceride-rich lipoproteins as well as lipolysis in the VLDL-IDL-LDL cascade regulate properties of LDL.
Juha Vakkilainen, Matti Jauhiainen, Kati Ylitalo, Ilpo O. Nuotio, Jorma S.A. Viikari, Christian Ehnholm, Marja-Riitta Taskinen   +6 more
doaj   +1 more source

Relationship between subclasses low-density lipoprotein and carotid plaque

Translational Neuroscience, 2022
Low-density lipoprotein (LDL) cholesterol can lead to the occurrence of atherosclerotic plaques, but patients with normal LDL still have atherosclerotic plaques in clinical practice.
Pan Zhanhai, Guo Huiwen, Wang Qingqing, Tian Sha, Zhang Xiaoxuan, Li Chengbo, Ma Zheng   +6 more
doaj   +1 more source

Carbamylated low-density lipoprotein induces endothelial dysfunction [PDF]

, 2017
Aims Cardiovascular events remain the leading cause of death in Western world. Atherosclerosis is the most common underlying complication driven by low-density lipoproteins (LDL) disturbing vascular integrity.
Akhmedov, Alexander, Camici, Giovanni G., Cvija, Hrvoje, Fliser, Danilo, Frenzel, Felix L., Heine, Gunnar H., Holy, Erik W., Jankowski, Joachim, Jankowski, Vera, Lüscher, Thomas F., Owala, Frederick O., Razavi, Marjan, Rohrer, Lucia, Seiler, Sarah, Speer, Thimoteus, Stähli, Barbara E., Tanner, Felix C., Triem, Sarah, Zewinger, Stephen   +18 more
core  

Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810] [PDF]

, 2002
Background Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its ...
Koroleva NS, ER Farnworth, AS Akalin, A Beena, SE Gilliland, H Nakajima, DR Rao, M Agaerbaeck, G Hepner, B Richelsen, G Schaafsma, KA Steinmetz, MC Bertolami, JE Rossouw, LU Thompson, NM de Roos, WP Charteris, WT Friedewald, J Folch, PJH Jones, JD Erfle, RJ Carman, P Marteau, TMS Wolever, GJ Buonopane, A Golay, M Saxelin   +26 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

ApoE genotype-specific inhibition of apoptosis

Journal of Lipid Research, 2003
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins ...
Robert M. DeKroon, Mirta Mihovilovic, Zoe V. Goodger, Jennifer B. Robinette, Patrick M. Sullivan, Ann M. Saunders, Warren J. Strittmatter   +6 more
doaj   +1 more source

Generation of Intracellular Signals by Low Density Lipoprotein Is Independent of the Classical LDL Receptor [PDF]

, 2017
Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 μg/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsPa) formation in vascular smooth muscle cells and fibroblasts. Low density lipoprotein cholesterol (15
Locher, Rudolf, Sachinidis, Agapios, Vetter, Wilhelm   +2 more
core  

Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women [PDF]

, 2001
We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty acids is related to increased risk of CHD, probably through
Bots, M.L., Katan, M.B., Roos, N.M., de
core   +2 more sources