Results 61 to 70 of about 585,583 (302)

Low density lipoprotein misfolding and amyloidogenesis

The FASEB Journal, 2008
ABSTRACT In early atherogenesis, subendothelial retention of lipidic droplets is associated with an inflammatory response‐to‐injury, culminating in the formation of foam cells and plaque. Low density lipoprotein (LDL) is the main constituent of subendothelial lipidic droplets.
Parasassi, T., De Spirito, Marco, Mei, G., Brunelli, R., Greco, G., Lenzi, L., Maulucci, Giuseppe, Nicolai, E., Papi, Massimiliano, Arcovito, G., Tosatto, S. C. E., Ursini, F.   +11 more
openaire   +7 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution

Journal of Lipid Research, 2002
Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and ...
Susan J. Murdoch, Molly C. Carr, Hal Kennedy, John D. Brunzell, John J. Albers   +4 more
doaj   +1 more source

Oxidative Low Density Lipoprotein and Exercise: A Historical and Meta-Analysis [PDF]

, 2012
PURPOSE: The purpose of this study is to use the meta-analytic approach to determine the impact of exercise on oxidized low density lipoproteins in an adolescent population and the role of oxidized low density lipoprotein in the etiology of ...
Kilgore, Lon, Tailor, Nikita, Velasquez, Benito, Wyatt, Frank   +3 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Receptor-mediated low density lipoprotein catabolism in man.

Journal of Lipid Research, 1979
Binding of human low density lipoproteins (LDL) to their specific receptor on cultured cells can be inhibited by treatment with 1,2-cyclohexanedione which blocks a number of functionally significant arginyl residues on the apolipoprotein.
J Shepherd, S Bicker, A R Lorimer, C J Packard   +3 more
doaj   +1 more source

Biological, clinical and population relevance of 95 loci for blood lipids. [PDF]

, 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ...
Aulchenko, Yurii S, Barbalic, Maja, Bis, Joshua C, Chambers, John, Chasman, Daniel I, Croteau-Chonka, Damien C, Edmondson, Andrew C, Feitosa, Mary F, Fouchier, Sigrid W, Guo, Xiuqing, Hua Zhao, Jing, Isaacs, Aaron, Jin Go, Min, Jin Kim, Young, Johansen, Christopher T, Johnson, Toby, Kim, Kyunga, Koseki, Masahiro, Lamina, Claudia, Lange, Leslie A, Lee, Jong-Young, Li, Mingyao, Li, Xiaohui, Luan, Jian'an, McCarthy, Mark I, McPherson, Ruth, Meitinger, Thomas, Melander, Olle, Montgomery, Grant W, Musunuru, Kiran, Nickerson, Deborah A, Nieminen, Markku S, O'Donnell, Christopher J, Oostra, Ben A, Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Parker, Alex N, Pattaro, Cristian, Pedersen, Nancy L, Peloso, Gina M, Penninx, Brenda WJH, Perola, Markus, Pichler, Irene, Pirruccello, James P, Pramstaller, Peter P, Psaty, Bruce M, Ricketts, Sally L, Rieder, Mark, Ripatti, Samuli, Roberts, Robert, Rose, Lynda M, Rudan, Igor, Ruokonen, Aimo, Sabatti, Chiara, Saharinen, Juha, Salomaa, Veikko, Sanna, Serena, Schlessinger, David, Scott, James, Scuteri, Angelo, Shin Cho, Yoon, Sijbrands, Eric JG, Silander, Kaisa, Sim, Xueling, Sinisalo, Juha, Smit, Johannes H, Smith, Albert V, Smith, Joshua D, Song, Kijoung, Soranzo, Nicole, Spector, Tim D, Stringham, Heather M, Stylianou, Ioannis M, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thompson, John R, Thorleifsson, Gudmar, Tuomilehto, Jaakko, Twee-Hee Ong, Rick, Uda, Manuela, Uitterlinden, Andre G, Vitart, Veronique, Voight, Benjamin F, Vollenweider, Peter, Waeber, Gérard, Wareham, Nicholas J, Waterworth, Dawn M, Whitfield, John B, Wichmann, H-Erich, Willemsen, Gonneke, Willer, Cristen J, Wilson, James F, Witteman, Jacqueline CM, Wright, Alan F, Yuan, Xin, Zee, Robert YL, Zhang, Weihua, Ziegler, Andreas   +99 more
core  

Proteins and Lipoproteins in Yolk From Eggs of the Estuarine Crocodile (Crocodylus porosus): A Comparison With Egg Yolk Of The Hen (Gallus domesticus) [PDF]

, 1988
1. The livetin patterns of the two species Crocodylus porosus and Gallus domesticus were very different and it was difficult to find a correspondence. 2. In C. porosus the granules were a larger proportion of the total yolk but they contained very little
Bligh, Burley, Burley, Burley, Clark, Evans, Glass, Grigg, Grigg, Hegenauer, Jenkins, Vadehra, Wallace, Williams   +13 more
core   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Charge properties of low density lipoprotein subclasses

Journal of Lipid Research, 1997
Measurements of electrophoretic mobility and particle size of low density lipoproteins (LDL) allowed use of standard electrokinetic theory to quantitate LDL charge characteristics from subjects with predominance of large LDL (pattern A, n = 9) or small ...
M La Belle, P J Blanche, R M Krauss
doaj   +1 more source