Results 231 to 240 of about 11,220,800 (302)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Therapeutic Efficacy of Metronomic Doxorubicin and Low Dose of Gamma Radiation on Breast Cancer Model. [PDF]

Cell Biochem Funct
Abdelrahman IY, Saif-Elnasr M, Attia ZR, Abd El Azeem RA, Khalifa E, Askar MA.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Pain in the heart, hair on the head: Pericarditis as an unanticipated risk of low-dose oral minoxidil. [PDF]

JAAD Case Rep
Zappi I, Spindler A, Maas D, Yaghoobzadeh H, Lo Sicco KI, Shapiro J.   +5 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Effectiveness and Safety of Prophylactic Low-Dose Emicizumab in Young Children With Hemophilia A: A Multicenter Retrospective Study. [PDF]

EJHaem
Zhou G, He L, Wang C, Deng Y, Peng D, Liu Z, Liu S, Fu X, Wang Y, Feng X.   +9 more
europepmc   +1 more source

Effects of Fractionated Low Dose Ionizing Radiation on Cellular Senescence in Mouse Lung Tissue. [PDF]

FASEB J
Zhang L, Cai L, Cai Y, Ke W, Zhou L, Zhou X, Ran R, Wang X, Yang Y, Huang W, Zou J, Chen H.   +11 more
europepmc   +1 more source

Low-Dose Corticosteroid Combined with Hydroxychloroquine for the Treatment of Generalized Annular Atrophic Lichen Planus: A Case Report. [PDF]

Clin Cosmet Investig Dermatol
Xu J, Chai L.
europepmc   +1 more source

Assessing a low-dose copper treatment for dreissenid mussels: Effects on zebra mussel (Dreissena polymorpha) population. [PDF]

Environ Manage
Barbour MT, Luoma JA, Dahlburg A, Severson TJ, Wise JK, Meulemans MJ, Bennie B, Hammond D, Waller D.   +8 more
europepmc   +1 more source