Results 101 to 110 of about 9,693,841 (256)

Low Doses of Radiation Reduce Risk

Dose-Response, 2007
The “Linear No Threshold” hypothesis, used in all radiation protection practices, assumes that all doses, no matter how low, increase the risk of cancer, birth defects and heritable mutations.
R. E. J. Mitchel
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Selective toxicity at low toxicant doses

, 2011
During the last decade, the paradigm that low toxicant doses often have stimulatory effects on plants has become widely accepted. At the same time, low toxicant doses of metal salts have been observed to inhibit the growth of the most vigorous seedlings ...
Myyrä, Mervi, Penttinen, Olli-Pekka, Sinkkonen, Aki, Rantalainen, Anna-Lea   +3 more
core   +3 more sources

In Vitro Study of Interleukin-6 when Used at Low Dose and Ultra-Low Dose in Micro-Immunotherapy

Life
As one of the major cytokines implicated in the orchestration of immune responses, interleukin 6 (IL-6) can either act as a pro- or an anti-inflammatory factor, depending on the micro-environment.
Camille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Mathieu Riffault, Ilaria Floris   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Patients’ education as a factor for arterial hypertension effective control – NOCTURNE Program

Кардиоваскулярная терапия и профилактика, 2006
Aim. To assess effectiveness of Health School for arterial hypertension (AH) patients in NOCTURNE Program. Material and methods. An open, multi-center, prospective study was performed in 14 Russian regions, involving 140 primary health doctors and 1195 ...
A. M. Kalinina, R. G. Oganov, D. V. Nebieridze   +2 more
doaj  

Application of different radiation health risk metrics in medical exposure

Радиационная гигиена
In recent years, several methodological documents have been approved and a number of scientific articles have been published concerning the assessment of radiation risks associated with medical exposure.
L. V. Repin, A. M. Biblin, A. V. Vodovatov, R. R. Akhmatdinov   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source