Results 61 to 70 of about 591,139 (353)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Low-Thrust Transfer Design of Low-Observable Geostationary Earth Orbit Satellite

International Journal of Aerospace Engineering, 2015
With radar and surface-to-air missiles posing an increasing threat to on-orbit spacecraft, low-observable satellites play an important role in low-thrust transfers.
Bing Hua, Zhujun Shao
doaj   +1 more source

Handover Solutions for 5G Low-Earth Orbit Satellite Networks

IEEE Access, 2022
Low-Earth orbit (LEO) satellite networks are meant to be fundamental to closing the digital divide, enabling new market opportunities and providing fifth-generation (5G) New Radio (NR) connectivity everywhere at any time.
Enric Juan, Mads Lauridsen, Jeroen Wigard, Preben Mogensen   +3 more
doaj   +1 more source

Asteroid resource map for near-Earth space [PDF]

, 2011
Most future concepts for the exploration and exploitation of space require a large initial mass in low Earth orbit. Delivering this required mass from the Earth’s surface increases cost due to the large energy input necessary to move mass out of the ...
McInnes, Colin, Sanchez Cuartielles, Joan-Pau   +1 more
core   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Thermal deformation of 3U CubeSat in low Earth orbit

MATEC Web of Conferences, 2018
The impact of uneven heating on a satellite structure in low Earth orbit has been considered using the example of 3U CubeSat. The calculations showed that the thermal deformation of CubeSat structure in orbit caused a deviation between normals to ...
Gorev Vasily, Pelemeshko Anatoly, Zadorozhny Alexander, Sidorchuk Aleksey   +3 more
doaj   +1 more source

Fused Low-Earth-Orbit GNSS

IEEE Transactions on Aerospace and Electronic Systems
Traditional Global Navigation Satellite System (GNSS) immunity to interference may be approaching a practical performance ceiling. Greater gains are possible outside traditional GNSS orbits and spectrum. GNSS from low Earth orbit (LEO) has long been viewed as promising but expensive, requiring large constellations for rapid navigation solutions.
Peter A. Iannucci, Todd E. Humphreys
openaire   +2 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source