Results 81 to 90 of about 591,139 (353)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Comparing Analytical and Numerical Approaches to Meteoroid Orbit Determination using Hayabusa Telemetry [PDF]

, 2018
Fireball networks establish the trajectories of meteoritic material passing through Earth's atmosphere, from which they can derive pre-entry orbits. Triangulated atmospheric trajectory data requires different orbit determination methods to those applied to observational data beyond the Earth's sphere-of-influence, such as telescopic observations of ...
arxiv   +1 more source

Photon Spacecraft and Aerocapture: Enabling Small Low-Circular Orbiters at Mars and Venus [PDF]

arXiv, 2023
With advancements in low-cost launchers and small interplanetary spacecraft, NASA has recognized the potential of small missions to perform focused planetary science investigations at Mars and Venus. The EscaPADE, part of the NASA SIMPLEx program will deliver two small spacecraft to elliptical orbits around Mars using the Photon spacecraft.
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Real - Time Orbit Determination of Low Earth Orbit Satellites Using Radar System and SGP4 Model [PDF]

Journal of Astronomy and Space Sciences, 2003
In case that we independently obtain orbital informations about the low earth satellites of foreign countries using radar systems, we develop the orbit determination algorithm for this purpose using a SGP4 model with an analytical orbit model and the ...
Jae-Kwang Lee, Sung-Seub Lee, Jae-Cheol Yoon, Kyu-Hong Choi   +3 more
doaj   +1 more source

Pervasive Orbital Eccentricities Dictate the Habitability of Extrasolar Earths [PDF]

, 2010
The long-term habitability of Earth-like planets requires low orbital eccentricities. A secular perturbation from a distant stellar companion is a very important mechanism in exciting planetary eccentricities, as many of the extrasolar planetary systems are associated with stellar companions.
arxiv   +1 more source

Precise orbit and baseline determination for maneuvering low earth orbiters [PDF]

GPS Solutions, 2015
Orbital maneuvers are usually performed as needed for low earth orbiters to maintain a predefined trajectory or formation-flying configuration. To avoid unexpected discontinuities and to connect pre- and post-maneuver arcs with a minimal set of parameters, a maneuver has to be considered in the routine GPS-based orbit determinations.
Bing Ju, Defeng Gu, Thomas A. Herring, Gerardo Allende-Alba, Oliver Montenbruck, Zhengming Wang   +5 more
openaire   +5 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

The detection of ultra-relativistic electrons in low Earth orbit

Journal of Space Weather and Space Climate, 2018
Aims. To better understand the radiation environment in low Earth orbit (LEO), the analysis of in-situ observations of a variety of particles, at different atmospheric heights, and in a wide range of energies, is needed. Methods.
Katsiyannis Athanassios C., Dominique Marie, Pierrard Viviane, Rosson Graciela Lopez, Keyser Johan De, Berghmans David, Kruglanski Michel, Dammasch Ingolf E., Donder Erwin De   +8 more
doaj   +1 more source

Komet: A Serverless Platform for Low-Earth Orbit Edge Services [PDF]

Low-Earth orbit satellite networks can provide global broadband Internet access using constellations of thousands of satellites. Integrating edge computing resources in such networks can enable global low-latency access to compute services, supporting end users in rural areas, remote industrial applications, or the IoT.
arxiv   +1 more source