Results 111 to 120 of about 2,484,191 (321)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Investigation of the Female Athlete Triad in Japanese Elite Wheelchair Basketball Players

Medicina, 2019
Background and objectives: Para-sports have become increasingly competitive, necessitating greater physical activity; secondary disorder prevention is therefore crucial.
Yukiyo Shimizu, Hirotaka Mutsuzaki, Kaori Tachibana, Kazushi Hotta, Yasuyoshi Wadano   +4 more
doaj   +1 more source

Japanese female athletes with low energy availability exhibit low multiple food group intake and increased tartrate-resistant acid phosphatase 5b levels: a cross-sectional study

, 2022
Tatsuya Ishizu, Suguru Torii, Eri Takai, Nozomi Miura, Motoko Taguchi   +4 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dietary intake, energy availability, and power in men collegiate gymnasts

Frontiers in Sports and Active Living
IntroductionThe purpose was to examine the prevalence of low energy availability (LEA), explore dietary behaviors in men collegiate gymnasts (n = 14), and investigate the relationships between energy availability (EA), body composition, and plyometric ...
Nicholas M. Kuhlman, Margaret T. Jones, Margaret T. Jones, Andrew R. Jagim, Andrew R. Jagim, Meghan K. Magee, Luke Wilcox, Jennifer B. Fields, Jennifer B. Fields   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Athlete’s Body Image in the Context of Relative Energy Deficiency in Sport—A Scoping Review

Journal of Functional Morphology and Kinesiology
Background: Relative Energy Deficiency in Sport (REDs) results from an imbalance between energy intake and expenditure, leading to low energy availability (LEA) and impairments of physiological and/or psychological functions in female and male athletes ...
Tabea Ruscheck, Christine Kopp, Andreas M. Nieß, Daniel Haigis   +3 more
doaj   +1 more source

An enabling framework for carbon capture and storage (CCS) in Europe: An overview of key issues. CEPS Policy Brief No 2019/03, 23 September 2019 [PDF]

, 2019
here are few credible scenarios for reaching the EU’s long-term climate policy objectives, such as net-zero by 2050, without the large-scale deployment of CCS technology. Carbon capture and storage technology is a pre-requisite for the decarbonisation of
Bryhn, Julie, Elkerbout, Milan
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The harder the prep, the harder the recovery: a qualitative exploration of physique athlete perspectives on competition weight loss and restoration

Journal of the International Society of Sports Nutrition
Background There is growing recognition of Low Energy Availability (LEA) symptoms in physique sports, however there are no clear recovery guidelines.
Claire Buechel, Kate Pumpa, Naroa Etxebarria, Michelle Minehan   +3 more
doaj   +1 more source