Results 71 to 80 of about 9,461,915 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dehnratenabhängiges Verformungs- und Versagensverhalten von dünnen Blechen unter Scherbelastung

, 2022
In diesem Forschungsvorhaben wurden neun verschiedene Stahlblechwerkstoffe bzw. -varianten und zwei exemplarische zusätzliche Werkstoffe, ein Aluminium und ein Kupfer, bezüglich des Schubverhaltens untersucht.
Huberth, F., Klitschke, S., Troll, A.
core   +1 more source

Low-Fat Recipes for SPIN

, 2000
Since the introduction of the first version of the model checker SPIN in 1991, many papers have been written on improvements to the tool and on industrial applications of the tool. Less attention has been given to the pragmatic use of SPIN. This paper presents several techniques to optimise both the modelling and verification activities when using SPIN.
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal [PDF]

, 2014
A dose-response strategy may not only allow investigation of the impact of foods and nutrients on human health but may also reveal differences in the response of individuals to food ingestion based on their metabolic health status.
Buri, C., Vergères, G, Piya, Milan K. (R19111), Portmann, Reto, Kopf, Katrin Annika, Magali Chollet, Caroline Buri, Vionnet, Nathalie, Pralong, Franc̨ois, Laederach, K., Kopf-Bolanz, Katrin A., Chollet, Magali, Egger, L, Reto Portmann, Piya, Milan K, Gijs, Martin A., Buri, Caroline, Milan K. Piya, Egger, Lotti, Piya, Milan K., McTernan, P. G., Piya, M.K., Schwander, Flurina, Mcternan, Philip G., Gijs, MAM, Piya, MK, Gijs, Martin A M, Vionnet, N, Egger, L., Vergères, G., Schwander, F., McTernan, PG, Laederach, K, Lotti Egger, Portmann, R, Chollet, M, Kurt Laederach, Kopf-Bolanz, K.A., Gijs, M.A., Kopf-Bolanz, Katrin A, Schwander, F, Pralong, Francois P., Gijs, Martin A. M., Buri, C, Portmann, R., Vionnet, N., Philip G. McTernan, Chollet, M., McTernan, Philip G, Flurina Schwander, Vergeres, Guy, Nathalie Vionnet, François Pralong, Pralong, F, Kopf-Bolanz, KA, Pralong, F., Martin A.M. Gijs, McTernan, P.G., Guy Vergères, Laederach, Kurt, Katrin A. Kopf-Bolanz   +60 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source