Results 51 to 60 of about 791,366 (257)
, 2000 Since the introduction of the first version of the model checker SPIN in 1991, many papers have been written on improvements to the tool and on industrial applications of the tool. Less attention has been given to the pragmatic use of SPIN. This paper presents several techniques to optimise both the modelling and verification activities when using SPIN.
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
PRODUCTION OF LOW FAT AND HIGH FIBER CAKE. [PDF]
Journal of Food and Dairy Sciences, 2004 In this study, it was used 75% of sugar in cake were substituted by stevioside to give the equivalent sweetness of replaced sugar. Shortening was also substituted at 50% level by maltodextrin gel.
A. Abd EI-Hamied
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Medical Journal of Australia, 1957 Mrs. Stead and Mrs. Warren offer menus and methods of cooking designed to reduce the total daily fat intake from the customary 100 gm. of the average American diet to 25 or 50 gm. They make no discrimination among types of fats, since those most likely to be "related to" atherosclerosis, overweight, and diabetic problems have not been identified.
+4 more sources
Low-fat versus Low-carbohydrate Diet
Journal of Nature and Science of MedicineThe global obesity rate has risen significantly, prompting research into the optimal dietary strategies for weight loss, particularly in relation to macronutrient composition.
Dalal J. Alsharif
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source