Results 81 to 90 of about 20,823,904 (285)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Effect of Different Treatment Modalities on Masseter Inhibitory Reflex in Patients with Sleep Bruxism: A Case‒Control Study [PDF]
Iranian Journal of OrthodonticsAim: Sleep bruxism is a parafunctional oral habit frequently related to sleep arousal. The masseter inhibitory reflex (MIR) causes reflex inhibition of voluntary contractions of the elevator muscles induced by intense peri- or intraoral mechanical or ...
Nabaa Mousa +2 more
doaj +1 more source
Luminous fabric devices for wearable low-level light therapy
Biomedical Optics Express, 2013 In this paper, a flexible luminous fabric device was developed and investigated for wearable three-dimensionally fitted low-level light therapy. The fabric device exhibited excellent optical and thermal properties. Its optical power density and operating temperature were stable during usage for 10 hours.
Jing, Shen +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Low-Level Radioactive Waste Disposal in Texas: Transportation and Packaging
, 1985 Brochure describes the "methods followed during the [packing and transportation] phase of the [low-level radioactive waste] disposal program" (p. [2])
Texas Low-Level Radioactive Waste Disposal Authority
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Texas Low-Level Radioactive Waste Storage Facility December 1983
, 1983 Report of the design of a low-level radioactive waste disposal facility and summarized information relating to the infrastructure and how it will ...
Texas Low-Level Radioactive Waste Disposal Authority
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Texas Low-Level Radioactive Waste Transportation Cost Evaluation, December 1983
, 1983 Report of the design of a low-level radioactive waste disposal facility and summarized information relating to the costs it would/does ...
Texas Low-Level Radioactive Waste Disposal Authority
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source