Results 191 to 200 of about 266,175 (254)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Large Rectal Neuroendocrine Tumor Curatively Resected Using Loop Ligation Device. [PDF]

ACG Case Rep J
Matlack L, Abu S, Sirapu S, Mittal J, Reichenbach ZW, Simons M, McDonald N.   +6 more
europepmc   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Split Intein-Mediated Engineering of Bacteriocins Through Backbone Circularization, Modular Assembly of Chimeras, and Inducible Circularization. [PDF]

Biomolecules
Lafuente I, Sevillano E, Peña N, Collado C, Cintas LM, Hernández PE, Muñoz-Atienza E, Borrero J.   +7 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Endoscopic double-layer nylon rope ligation for rescue of gastric ulcer bleeding after failed OTSC treatment: A case report (with video). [PDF]

Medicine (Baltimore)
Wu D, Wei H, Sun DY, Wang XY.
europepmc   +1 more source

Correction: Birth weight, ototoxic medication, and surgical history predict individual hearing loss risks: a systematic review and meta-analysis. [PDF]

Front Pediatr
Luo H, He J, Chen D, Xu X, Zhao J, Yang X, Shi J.   +6 more
europepmc   +1 more source

Low excision and high suspension hemorrhoidectomy versus conventional Milligan-Morgan hemorrhoidectomy for mixed hemorrhoids: a 12-month prospective randomized controlled trial. [PDF]

BMC Surg
Shu Y, Deng H, Zhu J, Zhang C, Sun P, Wang F, Liu H.   +6 more
europepmc   +1 more source