Results 101 to 110 of about 8,090,991 (304)

High-Modulation-Efficiency Lithium Niobate Electro-Optic Modulator Based on Sunken Dual-Layer Electrode

Photonics
Electro-optic modulators with high bandwidth, high modulation efficiency, and low loss play a crucial role in many fields, such as artificial intelligence, analog communications, and satellite data links.
Yicheng Huang, Qing Liao, Yihui Yin, Zanhui Chen, Fabi Zhang, Tangyou Sun, Haiou Li, Meihua Shou   +7 more
doaj   +1 more source

Low-loss lange coupler

Electronics Letters, 1982
The use of air-bridge straps in place of bond wires on the Lange coupler on an alumina substrate is investigated. It is shown that the resultant coupler has lower loss when compared with a coupler using bond wires and is more suitable for mass production than the bond-wire type.
J.L. Hobdell, J.W. Biggin, K.S. Band
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Research on a New Structure of High-Birefringence, Low-Loss Hollow-Core Photonic Bandgap Fibre

Photonics
Hollow-core microstructured optical fibres exhibit excellent properties, such as a low loss, tuneable high birefringence, and low nonlinearity, finding extensive applications across communications, industry, agriculture, medicine, military, and sensing ...
Fang Tan, Shunfa Cui, Zhitao Zhang, Songsong Ge, Dexiao Chen, Yanke Zhang, Dechun Zhou   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optical properties of a low-loss polarization maintaining microfiber

, 2010
A polarization preserving single-mode microfiber was successfully fabricated by a flame brushing method. A polarization extinction ratio of 16dB is typically maintained through the device with excess loss of 0 ...
Brambilla, Gilberto, Jung, Yongmin, Richardson, David J.   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source