Results 71 to 80 of about 3,184,733 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Ultra-Broadband Conductor-Backed Coplanar Waveguide with Sine Edges

open access: yesSensors
In this paper, a conductor-backed coplanar waveguide with sine edges (CBCPW-SE), consisting of a conductor-backed coplanar with periodic sine edges supported by a dielectric substrate, is proposed as a promising new transmission line (TL) at millimeter ...
Tingting Xie   +4 more
doaj   +1 more source

Low loss three-dimensional metamaterial-based omega-net microwave lens

open access: yesEngineering and Applied Science Research, 2017
Straight forward design of a three-dimensional microwave lens operating from the X- to K-band is proposed. Two-dimensional Omega-net structures that proved to have a near-zero refractive index with low loss are used as a startup design, and later are ...
Nantakan Wongkasem, David Flores
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

An Enhanced Genetic Algorithm for Optimization of Seven-Tube Single-Ring Anti-Resonant Hollow-Core Fiber with Record-Low Loss and Single Mode

open access: yesPhotonics
An enhanced genetic algorithm (EGA) is proposed to optimize our previously reported seven-tube single-ring anti-resonant hollow-core fiber (SR-ARF) with a record-low loss of 4.30 dB/km at 1080 nm.
Wei Gao   +5 more
doaj   +1 more source

Low-loss hybrid plasmonic coupler

open access: yesOptics Express, 2019
We demonstrate a low-loss coupling scheme between a silicon photonic waveguide and a hybrid-plasmonic waveguide. Measured coupling efficiencies reach up to 94% or -0.27 dB. The metal-insulator-semiconductor structure is fabrication-tolerant and adaptable to a wide range of materials including those used in CMOS processes.
Daniel Chelladurai   +5 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Ultra-Compact ARCL-Based MEMS Radar Filter for Mobile Robotic Platforms

open access: yesMicromachines
To address the stringent requirements for miniaturization and high reliability in the perception systems of mobile robotic platforms, this article presents an ultra-compact bandpass filter based on air core recta-coax lines using micro-electro-mechanical
Yan Ding   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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