Results 91 to 100 of about 16,047,641 (362)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Vortex Mass in a Superfluid at Low Frequencies [PDF]

open access: yesPhysical Review Letters, 2007
An inertial mass of a vortex can be calculated by driving it round in a circle with a steadily revolving pinning potential. We show that in the low frequency limit this gives precisely the same formula that was used by Baym and Chandler, but find that the result is not unique and depends on the force field used to cause the acceleration.
David J. Thouless, James R. Anglin
openaire   +4 more sources

The Expected Mass Function for Low Mass Galaxies in a CDM Cosmology: Is There a Problem? [PDF]

open access: yes, 2001
It is well known that the mass function for_halos_ in CDM cosmology is a relatively steep power law for low masses, possibly too steep to be consistent with observations. But how steep is the_galaxy_ mass function? We have analyzed the stellar and gas mass functions of the first massive luminous objects formed in a \Lambda CDM universe, as calculated ...
arxiv   +1 more source

Forged in FIRE: cusps, cores and baryons in low-mass dwarf galaxies [PDF]

open access: yes, 2015
We present multiple ultrahigh resolution cosmological hydrodynamic simulations of M_★ ≃ 10^(4–6.3) M_⊙ dwarf galaxies that form within two M_(vir) = 10^(9.5–10) M_⊙ dark matter halo initial conditions.
J. Oñorbe   +7 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

THE MASS DISTRIBUTION OF COMPANIONS TO LOW-MASS WHITE DWARFS [PDF]

open access: yesThe Astrophysical Journal, 2014
Measuring the masses of companions to single-line spectroscopic binary stars is (in general) not possible because of the unknown orbital plane inclination. Even when the mass of the visible star can be measured, only a lower limit can be placed on the mass of the unseen companion.
Jeff J. Andrews   +2 more
openaire   +4 more sources

Low muscle mass, low muscle function, and sarcopenia in the urban and rural elderly

open access: yesScientific Reports, 2022
Health outcomes of the elderly vary between rural and urban areas. Sarcopenia is diagnosed as loss of muscle strength or impaired physical performance, namely “low muscle function” and low muscle mass.
Sung Woo Moon   +6 more
doaj   +1 more source

The origin of single low-mass WDs: another problem that consequential angular momentum loss in CVs might solve [PDF]

open access: yes, 2016
Low-mass helium-core white-dwarfs (WDs) with masses below 0.5 Msun are known to be formed in binary star systems but unexpectedly a significant fraction of them seem to be single. On the other hand, in Cataclysmic Variables (CVs) a large number of low-mass WD primary stars is predicted but not observed. We recently showed that the latter problem can be
arxiv   +1 more source

Visual orbit for the low-mass binary Gliese 22 AC from speckle interferometry [PDF]

open access: yesAstron.Astrophys. 406 (2003) 293-298, 2003
Based on 14 data points obtained with near-infrared speckle interferometry and covering an almost entire revolution, we present a first visual orbit for the low-mass binary system Gliese 22 AC. The quality of the orbit is largely improved with respect to previous astrometric solutions. The dynamical system mass is 0.592 +- 0.065 solar masses, where the
arxiv   +1 more source

THE EVOLUTION OF THE GALAXY STELLAR MASS FUNCTION AT z = 4–8: A STEEPENING LOW-MASS-END SLOPE WITH INCREASING REDSHIFT [PDF]

open access: yes, 2015
We present galaxy stellar mass functions (GSMFs) at z = 4–8 from a rest-frame ultraviolet (UV) selected sample of ∼4500 galaxies, found via photometric redshifts over an area of ∼280 arcmin2 in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy ...
Mimi Song   +18 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy