Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria [PDF]
American Journal of Pathology, 1999 Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the tubular uptake of macromolecules filtered through the glomerulus. To elucidate the role of megalin in vivo and to identify its endogenous ligands, we analyzed the proximal tubular function in mice ...
Pierre Aucouturier +2 more
exaly +4 more sources
Prevalence of low molecular weight proteinuria and Dent disease 1 CLCN5 mutations in proteinuric cohorts. [PDF]
Pediatr Nephrol, 2020 Dent disease type 1 (DD1) is a rare X-linked disorder caused mainly by CLCN5 mutations. Patients may present with nephrotic-range proteinuria leading to erroneous diagnosis of focal segmental glomerulosclerosis (FSGS) and unnecessary immunosuppressive treatments.The following cohorts were screened for CLCN5 mutations: Chronic Kidney Disease in Children
Beara-Lasic L +13 more
europepmc +4 more sources
The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria. [PDF]
Open Access Maced J Med Sci, 2018 BACKGROUND: Proteinuria, in addition to haematuria, is the most important laboratory parameter in patients with nephro-urological diseases. Low molecular weight proteinuria (LMWP) is of particular importance because some diseases genetic and tubulointerstitial are diagnosed based on its presence.AIM: The purpose of this study is to describe the ...
Salihu S +5 more
europepmc +4 more sources
Transgenic zebrafish modeling low-molecular-weight proteinuria and lysosomal storage diseases [PDF]
Kidney International, 2020 Epithelial cells lining the proximal tubule of the kidney reabsorb and metabolize most of the filtered low-molecular-weight proteins through receptor-mediated endocytosis and lysosomal processing. Congenital and acquired dysfunctions of the proximal tubule are consistently reflected by the inappropriate loss of solutes including low-molecular-weight ...
Chen, Zhiyong +6 more
openaire +5 more sources
Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]
, 2002 Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Fink, E. +6 more
core +1 more source
Noninvasive Urinary Monitoring of Progression in IgA Nephropathy. [PDF]
, 2019 Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity.
Fervenza, Fernando C +4 more
core +1 more source
Asymptomatic low molecular weight proteinuria.
Nihon Shoni Jinzobyo Gakkai Zasshi, 1997 特発性尿細管性蛋白尿症の母子例を含め3症例を報告した。小児の2例共男児で偶然の機会に尿検査にて異常が発見された。いずれもβ2ミクログロブリンおよび分子量約2.8万の尿中低分子蛋白が増加していた。全例糸球体濾過機能は正常で，発育障害は見られなかった。腎生検を施行した1例において，メサンギウム細胞の増殖はみられず，基質の増加が軽度見られ，またメサンギウム基質の硬化を認めた。
Kaori Tomonaga +3 more
openaire +2 more sources
Hypothyroidism and nephrotic syndrome: why, when and how to treat [PDF]
, 2017 Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS).
Barbano, Biagio +7 more
core +1 more source
Bartter-Like Syndrome as the Initial Presentation of Dent Disease 1: A Case Report
Frontiers in Pediatrics, 2021 Dent disease is a rare genetic disease characterized by low-molecular-weight proteinuria. Dent disease with Bartter-like syndrome is rare and can easily be misdiagnosed and mistreated. Herein, we report a case of Dent disease 1 with Bartter-like syndrome
Qiaoping Chen +4 more
doaj +1 more source
The Induction of Oxidative/Nitrosative Stress, Inflammation, and Apoptosis by a Ferric Carboxymaltose Copy Compared to Iron Sucrose in a Non-Clinical Model [PDF]
, 2015 Introduction: Ferric carboxymaltose is a next-generation polynuclear iron(III)-hydroxide carbohydrate complex for intravenous iron therapy belonging to the class of so-called non-biological complex drugs.
Angerosa, Margarita +2 more
core +1 more source