Results 61 to 70 of about 437,753 (253)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Low-Power Wide-Area Networks: Design Goals, Architecture, Suitability to Use Cases and Research Challenges

IEEE Access, 2020
Previous survey articles on Low-Powered Wide-Area Networks (LPWANs) lack a systematic analysis of the design goals of LPWAN and the design decisions adopted by various commercially available and emerging LPWAN technologies, and no study has analysed how ...
Ben Buurman, Joarder Kamruzzaman, Gour Karmakar, Syed Islam   +3 more
doaj   +1 more source

Low-Power Wide-Area Network Over White Spaces

IEEE/ACM Transactions on Networking, 2018
As a key technology driving the Internet-of-Things, low-power wide-area networks (LPWANs) are evolving to overcome the range limits and scalability challenges in traditional wireless sensor networks. This paper proposes a new LPWAN architecture called sensor network over white spaces (SNOW) by exploiting the TV white spaces.
Abusayeed Saifullah, Mahbubur Rahman 0001, Dali Ismail, Chenyang Lu 0001, Jie Liu 0001, Ranveer Chandra   +5 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Contender waveforms for Low-Power Wide-Area networks in a scheduled 4G OFDM framework

EURASIP Journal on Advances in Signal Processing, 2018
When designing new solutions for Low-Power Wide-Area (LPWA) networks, coexistence and integration into existing 4G frameworks should be considered to ease the deployment procedure and reduce costs.
Yoann Roth, Jean-Baptiste Doré, Laurent Ros, Vincent Berg   +3 more
doaj   +1 more source

Survey on Low Power Wide Area Networks in IoT

2020 International Conference on Smart Systems and Technologies (SST), 2020
Communication technologies, aimed at providing effective wireless communication, form one of the cornerstones of the wide adoption of Internet of Things (IoT). Low-Power Wide-Area (LPWA) wireless communication technologies are particularly suited for implementation of Machine-to-Machine (M2M) communication in usage contexts where low data rate and low ...
Katušić, Damjan, Skočir, Pavle, Kušek, Mario, Čavrak, Igor   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Surrogate Model-Based Energy-Efficient Scheduling for LPWA-Based Environmental Monitoring Systems

IEEE Access, 2018
The rapid development of the Internet of Things (IoTs) with newly proposed wireless communication technology has compactly generated connections between humans and the physical world.
Jin Tong, Mingjian Cui, Meng Tian, Yigang He   +3 more
doaj   +1 more source