Results 71 to 80 of about 20,582,399 (283)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Low-Power Wide Area Network (LPWAN) Overview
, 2018 Internet Engineering Task Force (IETF) Request for Comments (RFC) 8376Low-Power Wide Area Networks (LPWANs) are wireless technologies withcharacteristics such as large coverage areas, low bandwidth, possiblyvery small packet and application-layer data ...
Gomez, Carles +12 more
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
RPMA low-power wide-area network planning method based on data mining
Tongxin xuebao, 2019 A network planning method based on data mining was proposed for RPMA low-power wide-area network with large density of base stations and uneven traffic distribution.First,a signal quality prediction model was established by using the boosting regression ...
Xiaorong ZHU, Yao SHEN
doaj +2 more sources
Low-Power Wide-Area Network Over White Spaces
IEEE/ACM Transactions on Networking, 2018 As a key technology driving the Internet-of-Things, low-power wide-area networks (LPWANs) are evolving to overcome the range limits and scalability challenges in traditional wireless sensor networks. This paper proposes a new LPWAN architecture called sensor network over white spaces (SNOW) by exploiting the TV white spaces.
Abusayeed Saifullah +5 more
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A Comparison of Physical Layers for Low Power Wide Area Networks [PDF]
, 2016 In Low Power Wide Area networks, terminals are expected to be low cost, low power and able to achieve successful communication at long range. Communication should be low rate compared to cellular mobile networks. Most of the current technologies dedicated to Machine-to-Machine communication rely on the use of a spreading factor to achieve low levels of
Roth, Yoann +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source