Results 91 to 100 of about 6,107,983 (353)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
When intracranial pressure is low [PDF]
Tidsskrift for Den norske legeforening, 2021 Johannes Sverre, Willumsen +2 more
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Study on Fire Characteristics of Flame-Retardant Polycarbonate Under Low Pressure
FireThis work presents experimental and numerical research on the pyrolysis and combustion characteristics of flame-retardant polycarbonate under low ambient pressure.
Zhuoer Sun, Xuehui Wang, Jian Wang
doaj +1 more source
Matching flow characteristics of standard shutoff valves eliminates need for custom fabricated valves [PDF]
, 1966 Standard high pressure valves are used in low pressure fluid system testing when a substantial system pressure increase is required. The flow-vs-valve stroke is matched with that of the valves being replaced.
Bevan, A. F.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Interaction between the Intergalactic Medium and Galactic Outflows from Dwarf Galaxies
, 1999 We have carried out 2D hydrodynamical simulations in order to study the interaction between supernova-powered gas outflows from low-mass galaxies and the local intergalactic medium (IGM).
Babul, A., Murakami, I.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source