Results 91 to 100 of about 12,376,341 (299)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Fabrication and Characterization of Metal Matrix Composites by Low Pressure Infiltration Method [PDF]
, 2006 The microstructure control technique and mechanical properties of particle or randomly oriented fiber reinforced metal matrix composites fabricated by LPI process were examined. SiC particles and fibers were used as reinforcement, while Al-4mass%Cu alloy,
香川, 明男 +2 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Study on Fire Characteristics of Flame-Retardant Polycarbonate Under Low Pressure
FireThis work presents experimental and numerical research on the pyrolysis and combustion characteristics of flame-retardant polycarbonate under low ambient pressure.
Zhuoer Sun, Xuehui Wang, Jian Wang
doaj +1 more source
Low pressure solar thermal converter
, 2009 The current development of solar power converters with air as working fluid focuses mostly on concentrating collectors combined with hot-air engines, and on very low temperature solar tower concepts.
Muller, Gerald, Gerald Müller
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Effect of Manipulation and Mobilisation on Pressure Pain Thresholds in the Thoracic Spine [PDF]
, 2004 High velocity low amplitude (HVLA) thrust manipulation and mobilisation are commonly used by manual therapists to relieve spinal pain and improve mobility. The aim of this controlled, single blinded study was to investigate the effect of manipulation and
Fryer, Gary, Carub, Joanne, McIver, S
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source