Results 31 to 40 of about 576,467 (215)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Design of a Linear Floating Active Resistor with Low Temperature Coefficient

Chips
This paper presents the design and implementation of a linear, stable, low-power and PVT insensitive floating active resistor, which is realized using TSMC 40 nm CMOS process technology.
Yu Liu, Pak Kwong Chan
doaj   +1 more source

Establishment of Combustion Model for Isooctane HCCI Marine Diesel Engine and Research on the Combustion Characteristic

MATEC Web of Conferences, 2016
The homogeneous charge compression ignition (HCCI) combustion mode applied in marine diesel engine is expected to be one of alternative technologies to decrease nitrogen oxide (NOX) emission and improve energy utilization rate.
Li Biao, Gao Hongtao
doaj   +1 more source

DNS of compressible turbulent channel flow subject to strong temperature gradient

Nihon Kikai Gakkai ronbunshu, 2016
A direct numerical simulation of compressible turbulent channel flow at low Mach number(Ma = 0.3) subject to strong temperature gradient is conducted. The wall temperature ratios which are defined by a temperature on the upper wall divided by that on the
Mitsuhiro NAGATA, Makoto NAGAOKA
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Kinetic Study on Lubricity of MoDTC as a Friction Modifier

Tribology Online, 2019
The temperature dependence of friction coefficient of lubricant oils containing MoDTC was evaluated using a ball on disk tribometer at constant temperatures of 25, 40, 60 and 80°C.
Masanori Komaba, Shinya Kondo, Atsushi Suzuki, Kazue Kurihara, Shigeyuki Mori   +4 more
doaj   +1 more source

Effect of temperature on the frictional behavior of 18CrNiMo7-6 under lubrication

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2022
In the process of gear meshing, the tooth surface will produce friction heat, which will in turn act on the friction coefficient. The temperature does not directly affect the friction coefficient of the gear tooth surface, but indirectly through ...
Fei LIU, Yonghong CHEN, Heping XIE, Chenyang DOU, Bingkui CHEN   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Thermo-electrochemical redox flow cycle for continuous conversion of low-grade waste heat to power

Scientific Reports, 2022
Here we assess the route to convert low grade waste heat (
Jorrit Bleeker, Stijn Reichert, Joost Veerman, David A. Vermaas   +3 more
doaj   +1 more source