Results 91 to 100 of about 15,861,332 (312)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Riemann-Hilbert approach for the integrable nonlocal nonlinear Schr\"odinger equation with step-like initial data

Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2018
We study the Cauchy problem for the integrable nonlocal nonlinear Schr\"odinger (NNLS) equation \[ iq_{t}(x,t)+q_{xx}(x,t)+2 q^{2}(x,t)\bar{q}(-x,t)=0 \] with a step-like initial data: $q(x,0)=o(1)$ as $x\to-\infty$ and $q(x,0)=A+o(1)$ as $x\to\infty ...
Ya. Rybalko, D. G. Shepelsky
doaj  

Snap-through transition of buckled graphene membranes for memcapacitor applications

Scientific Reports, 2018
Using computational and theoretical approaches, we investigate the snap-through transition of buckled graphene membranes. Our main interest is related to the possibility of using the buckled membrane as a plate of capacitor with memory (memcapacitor ...
Ruslan D. Yamaletdinov, Oleg V. Ivakhnenko, Olga V. Sedelnikova, Sergey N. Shevchenko, Yuriy V. Pershin   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Low Temperature LiTaO3-To-Si Wafer Bonding

In this study, the low-Temperature bonding of lithium tantalate (LiTaO3)-To-silicon (Si) was investigated using plasma activation.
Wuensch, Dirk, Wiemer, Maik, Schulz, Stefan E., Richter, Dominic, Stoll, Fiete, Dubey, Vikas   +5 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

LOW TEMPERATURE DEFORMATION AND STRENGTH OF POLYIMIDE FILMS DUE TO THICKNESS AND DEFORMATION SPEED

East European Journal of Physics, 2017
In work mechanical properties of polyimide films analogue kapton H (manufactures of the People's Republic of China) with different thickness in the temperature interval 77-293 K and deformation speed interval 10-4-10-3 s-1 are carried out.
V. A. Lototskaya, L. F. Yakovenko, E. N. Aleksenko, V. V. Abraimov, Wen Zhu Shao   +4 more
doaj  

Governing of the piezoelectric effect by external fields and strains

Scientific Reports
Piezoelectricity in quantum rare-earth metallic boron oxides with the coupling between magnetic, electric and elastic subsystem is studied theoretically. It is proved that the change of piezoelectric modules of the considered crystals are proportional to
A. A. Zvyagin, V. V. Slavin
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Deep ice coring at Dome Fuji Station, Antarctica

Antarctic Record, 1999
Deep ice coring was carried out at Dome Fuji Station, Antarctica in 1995 and 1996 following a pilot borehole drilled and cased with FRP pipes in 1993,and reached 2503.52m in December 1996.
Yoshiyuki Fujii, Nobuhiko Azuma, Yoichi Tanaka, Akiyoshi Takahashi, Kunio Shinbori, Yoshiki Nakayama, Hideaki Motoyama, Kazuo Katagiri, Shuji Fujita, Morihiro Miyahara, Takao Kameda, Takashi Saito, Takeshi Saito, Hitoshi Shoji, Takayuki Shiraiwa, Hideki Narita, Kokichi Kamiayma, Teruo Furukawa, Hideo Maeno, Hiroyuki Enomoto, Renji Naruse, Kotaro Yokoyama, Takeo Hondo, Yutaka Aageta, Kunio Kawada, Okitsugu Watanabe   +25 more
doaj   +1 more source