Results 101 to 110 of about 15,861,332 (312)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Performance of Thermosyphon Rankine Engine as Low Temperature Heat Engine
, 2020 Energy harvesting from the low-temperature heat source can be applied from thermosyphon rankine engine (TSR), this devicedepends on rankine cycle where evacuation the pressure from the device will decrease evaporation pressure according to appliedpressure. This engine was developed in little experiments, so a new model was constructed depending on last
openaire +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Josephson weak link based on proximity effect in long bi-metallic thin-film bridge
AIP AdvancesWe prepared a bi-metal Sn/Al thin film bridge of 1 × 5 µm2 in size and exposed it to microwave irradiation in a frequency range of 7 to 40 GHz to explore the Shapiro steps in the current-voltage characteristics, which served as a reliable indicator for ...
O. G. Turutanov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
PlasmaThe fabrication of semiconductor devices with three-dimensional architectures imposes unprecedented demands on advanced plasma dry etching processes. These include the simultaneous requirements of high throughput, high material selectivity, and precise ...
Shigeyuki Takagi +4 more
doaj +1 more source
A LOW TEMPERATURE DIFFERENCE HEAT ENGINE
This work presents a novel expansion engine operating on a Quasi-Carnot cycle, combining quasi-isothermal and quasi-adiabatic processes. The design integrates thermal energy storage and heat exchange directly within the engine, utilizing alternating hot and cold water sprays to sustain near-isothermal compression and expansion, thereby minimizing ...
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Pre-ignition associated with low-temperature shock tube ignition measurements
, 2015 Shock tubes are widely used for chemical kinetics studies due to their ability to instantaneously achieve nearly zero-dimensional high-temperature conditions behind reflected shock waves.
Es-sebbar, Et-touhami +5 more
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source