Results 81 to 90 of about 15,861,332 (312)
On laser desorption/ionization mass spectrometry of molybdenum disulfide 2D nanomaterial
Хімія, фізика та технологія поверхніMass spectrometric characterization of non-molecular nanomaterials has its distinctive features as compared to analysis of molecular substances. Namely, not an individual molecular ion, but a set of charged clusters is usually sputtered from solid ...
O. A. Boryak +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
AIP Advances, 2015 The temperature dependences of the elastic and magnetic properties of polycrystalline perovskite manganite La2/3Ba1/3MnO3 were studied using ultrasonic and SQUID magnetometer techniques.
E. Fertman +9 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
THE LATTICE PARAMETERS AND RESIDUAL STRESSES IN BULK NANOCRYSTALLINE AND ULTRAFINE-GRAINED TITANIUM
East European Journal of Physics, 2017 Lattice parameters and residual stresses in the bulk nanocrystalline/ultrafine-grained titanium were studied by X-ray diffraction methods. The investigated samples were prepared using the method of the cryomechanical grain structure fragmentation with ...
Yu. M. Plotnikova +3 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
EnergiesEfficient reinjection is critical for maintaining reservoir pressure and ensuring the sustainable development of sandstone geothermal systems. However, complex thermal–hydraulic–chemical (THC) interactions often lead to progressive permeability reduction,
Miaoqing Li +10 more
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The Effect of Reduction Temperature of Graphene Oxide on Low Temperature Hydrogen Sorption [PDF]
Журнал нано- та електронної фізики, 2015 Sorption and subsequent desorption of hydrogen by graphene oxide powder which was thermally redu-ced at temperatures of 200, 300, 500, 700 and 900 °С were investigated in 9-290 K temperature interval.
A.V. Dolbin +7 more
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