Results 111 to 120 of about 275,272 (246)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Impact of Aging and Low Temperatures on the Mechanical Properties of Low-Cost Seismic Isolator Prototypes

Buildings
Seismic isolation systems are an effective passive protection strategy that decouples structures from ground motion. Their performance depends heavily on the elastomeric materials used, which must retain mechanical integrity under environmental stressors.
Isabel C. Velasco-Cuervo, Erika D. Lemos-Micolta, Ingrid E. Madera-Sierra, Manuel Alejandro Rojas-Manzano, Mario F. Muñoz-Velez, Orlando Cundumí, Edwin Patino, Manuel Salmeron-Becerra, Shirley J. Dyke, Mirian Velay-Lizancos   +9 more
doaj   +1 more source

Design and evaluation of low-frequency RFID transponder for cryogenic applications

, 2022
S.40-44Electronic identification of cryobiological specimens is an emerging technology in the field of advanced biological specimen banking. In this paper, we focus on the design and evaluation of a radio-frequency identification transponder (RFID) using
Ihmig, F., Zimmermann, H.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

First year growth in the lithodids Lithodes santolla and Paralomis granulosa reared at different temperatures [PDF]

, 2005
The southern king crab, Lithodes santolla Molina, and stone crab, Paralomis granulosa Jacquinot, inhabit the cold-temperate waters of southernmost South America (southern Chile and Argentina), where stocks of both species are endangered by overfishing ...
Calcagno, J.A., Thatje, S., U. Nettelmann, Lovrich, G.A., Anger, K., S. Thatje, Nettelmann, U., Calcagno, Javier Ángel, G.A. Lovrich, Anger, Klaus, K. Anger, Lovrich, Gustavo Alejandro, Calcagno, J. A., Lovrich, G. A., Nettelmann, Uwe, J.A. Calcagno   +15 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Recovery Dynamics of Photosynthetic Performance and Antioxidant Defense in Resurrection Plants Ramonda serbica and Ramonda nathaliae After Freezing-Induced Desiccation

Plants
Resurrection plants such as Ramonda serbica and Ramonda nathaliae are gaining scientific attention due to their exceptional ability to withstand extreme drought and cold.
Bekim Gashi, Fitim Kastrati, Gergana Mihailova, Katya Georgieva, Eva Popova, Erzë Çoçaj, Kimete Lluga-Rizani, Qëndrim Ramshaj   +7 more
doaj   +1 more source

Evolution of Interfacial Features of MnO-SiO2 Type Inclusions/Steel Matrix during Isothermal Heating at Low Temperatures

High Temperature Materials and Processes, 2019
To clarify the evolution of interfacial features between MnO-SiO2 type inclusions and Si-Mn killed steel during isothermal heating at low temperatures, two diffusion couple samples were investigated under heat treatment at 1173 K and 1273 K, respectively.
Zhang Xueliang, Yang Shufeng, Li Jingshe, Liu Chengsong, Hao Wei-xing   +4 more
doaj   +1 more source

Effect of Oil on Flow Boiling Heat Transfer and Flow Patterns of CO2 in 11.2 mm Horizontal Smooth and Enhanced Tube

, 2012
Flow boiling heat transfer characteristics of CO2 with and without oil were investigated experimentally in horizontal smooth and enhanced tubes with an inner diameter of 11.2 mm.
Hrnjak, Predrag S., Kim, Seongho
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source