Results 91 to 100 of about 957,129 (290)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Experimental investigation of glass-carbon/epoxy hybrid composites subjected to low velocity impact test [PDF]

FME Transactions, 2018
Hybrid composites with multiple reinforcements of high strength are very popular for many engineering applications, especially for impact resistance. In the present work, we report the development of the glasscarbon/ epoxy hybrid composites using hand ...
Venkategowda C., Rajanna S., Udupa N.G.S., Keshavamurthy R.   +3 more
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Simulation on low velocity impact to GLARE laminate based on ABAQUS

Journal of Aeronautical Materials, 2019
The material behavior of glass fiber reinforced aluminum laminates (GLARE) under low-speed impact of a falling hammer was studied, and a finite element model of ABAQUS for simulation and experimental verification was built.
CUI Xu, LI Bin, WANG Shuo, XUE Hongqian, ZHANG Zhenyu   +4 more
doaj   +1 more source

Nucleation in a Fermi liquid at negative pressure

, 2001
Experimental investigation of cavitation in liquid helium 3 has revealed a singular behaviour in the degenerate region at low temperature. As the temperature decreases below 80 mK, the cavitation pressure becomes significantly more negative.
Balibar, Sebastien, Caupin, Frederic, Maris, Humphrey J.   +2 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Experimental investigation on low-velocity impact behavior of glass, Kevlar, and hybrid composites with an elastomeric polyurethane matrix

Composites Part C: Open Access
Low-velocity impacts represent a critical dynamic condition for engineering structures. Combining two reinforcing fibers in a single matrix, i.e., hybridization, is considered a feasible way to improve composite performance.
Alessandro Vescovini, Joziel A. Cruz, Dayou Ma, Chiara Colombo, Antonio Salerno, Otavio Bianchi, Sandro C. Amico, Andrea Manes   +7 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source