Results 51 to 60 of about 215,695 (266)

Assessment of Numerical Simulation Models for Impact Damage of Composite Materials

Hangkong gongcheng jinzhan, 2019
Fiber reinforced resin matrix composites(FRP) have been widely used in aerospace and other advanced structures. The study of low-speed impact damage of FRP is of important engineering application value.
Zhang Jiarui, Wu Fuqiang, Yao Weixing
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Finite element analysis of localised impact loading on short glass fibrereinforced polyamide engine oil pan subjected to low velocity impact from flying projectiles [PDF]

, 2011
This paper investigates low velocity impact involving a glass fibre-reinforced polyamide engine oil pan as part of a complete new development of thermoplastic components.
Westwood, Keith, Mouti, Zakaria, Long, Darren, Njuguna, James A. K.   +3 more
core  

Fiber Metal Laminates under Low Velocity Impact: An Experimental / Analytical Approach [PDF]

علوم و تکنولوژی پلیمر, 2012
Fiber/ metal laminates (FMLs) are hybrid composites consisting of alternating thin layers of metal sheets and fiber reinforced epoxy laminates. In this study, the effect of fiber orientation on impact properties of FML plates is investigated both ...
mostafa sabzikar borojerdi, soheil daryoushi, Mojtaba sedighi   +2 more
doaj   +1 more source

Effect of repair parameters on composite plates under low velocity impact

European Mechanical Science, 2022
In this study, the impact behavior of patch-repaired layered composite plates under low velocity impact loads was numerically investigated. For this purpose, layered composite plates with holes with different geometries in the middle were repaired with ...
Mete Onur Kaman, Mustafa Albayrak, Mustafa Gür   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study of the behavior of damaged low-velocity impact carbon/epoxy/AL2024-T3 hybrid laminates

Discover Materials
Aluminium and layered composite structures currently play a crucial role in the aviation sector. These structures may be susceptible to inadvertent impacts from several sources.
Fatima Zohra Daouache, Amin Houari, Mourad Lounis, Lecheb Samir, Salah Amroune, Kouider Madani, Barhm Mohamad, Mohamed Belhouari   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of Glass Fiber Hybridization on the Behavior Under Impact of Woven Carbon Fiber/Epoxy Laminates

, 2010
The low-velocity impact behavior was studied in hybrid laminates manufactured by RTM with woven carbon and glass (S2) fabrics. Specimens with different thicknesses and glass fiber content (from 0 to 21 vol.%) were tested with impact energies in the range
Enfedaque Díaz, Alejandro
core   +1 more source